Evidence map›Paper›PMID 32781571›Full record

ReviewVaccines2020

Investigating Virological, Immunological, and Pathological Avenues to Identify Potential Targets for Developing COVID-19 Treatment and Prevention Strategies.

Zafar Mahmood, Hani Alrefai, Helal F Hetta, Hidaya A Kader, Nayla Munawar, Sheikh Abdul Rahman, Shereen Elshaer, Gaber Ei-Saber Batiha, Khalid Muhammad

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Zafar MahmoodLowance Center for Human Immunology, Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Hani AlrefaiDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.ORCID 0000-0002-2687-6487
Helal F HettaDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.ORCID 0000-0001-8541-7304
Hidaya A KaderDepartment of Biology, College of Science, United Arab Emirates University, Al Ain 15551, UAE.
Nayla MunawarDepartment of Chemistry, College of Science, United Arab Emirates University, Al Ain 15551, UAE.
Sheikh Abdul RahmanDivision of Microbiology and Immunology, Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-3832-2713
Shereen ElshaerCincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3026, USA.
Gaber Ei-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicines, Damanhour University, Damanhour 22511, Egypt.ORCID 0000-0002-7817-425X
Khalid MuhammadDepartment of Biology, College of Science, United Arab Emirates University, Al Ain 15551, UAE.ORCID 0000-0001-6488-1722
United Arab Emirates University · AEEmory University · USAssiut University · EGCincinnati Children's Hospital Medical Center · USDamanhour University · EGMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus causing respiratory disease commonly known as COVID-19. This novel coronavirus transmits from human to human and has caused profound morbidity and mortality worldwide leading to the ongoing pandemic. Moreover, disease severity differs considerably from individual to individual. Investigating the virology of COVID-19 and immunological pathways underlying its clinical manifestations will enable the identification and design of effective vaccines and potential therapies. In this review, we explore COVID-19 virology, the contribution of the immune system (innate and adaptive) during infection and control of the virus. Finally, we highlight vaccine development and implications of immune system modulation for potential therapeutic interventions to design better therapeutic strategies to guide future cure.

Indexed as

B cellsCOVID-19T cellsvaccine development

Identifiers

PMID32781571
PMCPMC7563267
OpenAlexW3047450097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.