Evidence map›Paper›PMID 32781308›Full record

ArticleEarly human development2020

Second to fourth digit ratio (2D:4D) is associated with dementia in women.

Joanne Jiang, Katherine Young, Christian J Pike

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Early human development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joanne JiangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Katherine YoungLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Christian J PikeLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: cjpike@usc.edu.

Funding

Sex differences in the relationship between APOE and AD: Role of sexual differentiationRF1AG058068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, LADU, MARY JO · 2017 to 2017
$3.8M
NIA NIH HHS RF1 AG058068
6 · The paper itself

Abstract

Alzheimer's disease is characterized by sex differences that may involve sex hormone exposure during development. Finger length ratios, an indirect measure of prenatal androgen exposure, were found to significantly differ in women with and without dementia. This finding links a relatively feminine in utero development with vulnerability to dementia in women.

Indexed as

AgedAged, 80 and overDementiaFemaleFingersHumansMaleSex FactorsAlzheimer's diseaseDementiaPrenatal androgensSex differencesSexual differentiation

Identifiers

PMID32781308
PMCPMC7484057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.