ArticleCortex; a journal devoted to the study of the nervous system and behavior2020
How functional network connectivity changes as a result of lesion and recovery: An investigation of the network phenotype of stroke.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Pooled it
- Effects of Motor Imagery Training Based on Near-Infrared Functional Brain Imaging on Upper Limb Function in Stroke Patients: A Randomized Controlled Trial.Brain topography · 2026Trial
- Motor network reorganization after motor imagery training in stroke patients with moderate to severe upper limb impairment.CNS neuroscience & therapeutics · 2023Trial
- Disrupted interhemispheric communication in primary progressive aphasia: a multimodal MRI study of homotopic connectivity.NeuroImage. Clinical · 2026Article
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Article
- Spatio-Temporal Signatures of Cognitive Function After Pediatric Arterial Ischemic Stroke-A Pilot Study.Human brain mapping · 2025Article
- Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia.Neurology international · 2024Article
- Remapping and Reconnecting the Language Network after Stroke.Brain sciences · 2024Review
- Modeling functional connectivity changes during an auditory language task using line graph neural networks.Frontiers in computational neuroscience · 2024Article
- Resting-State Connectivity in Acute and Subacute Poststroke Aphasia: A Functional Near-Infrared Spectroscopy Pilot Study.Brain connectivity · 2023Article
- Switching between External and Internal Attention in Hippocampal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The right hemisphere's capacity for language: evidence from primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Treatment-induced neural reorganization in aphasia is language-domain specific: Evidence from a large-scale fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- The analysis of brain functional connectivity of post-stroke cognitive impairment patients: an fNIRS study.Frontiers in neuroscience · 2023Article
- Inter-hemispheric synchronicity and symmetry: The functional connectivity consequences of stroke and neurodegenerative disease.NeuroImage. Clinical · 2022Article
- Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy.Brain and language · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This study, through a series of univariate and multivariate (classification) analyses, investigated fMRI task-based functional connectivity (FC) at pre- and post-treatment time-points in 18 individuals with chronic post-stroke dysgraphia. The investigation examined the effects of lesion and treatment-based recovery on functional organization, focusing on both inter-hemispheric (homotopic) and intra-hemispheric connectivity. The work confirmed, in the chronic stage, the "network phenotype of stroke injury" proposed by Siegel et al. (2016) consisting of abnormally low inter-hemispheric connectivity as well as abnormally high intra-hemispheric (ipsilesional) connectivity. In terms of recovery-based changes in FC, this study found overall hyper-normalization of these abnormal inter and intra-hemispheric connectivity patterns, suggestive of over-correction. Specifically, treatment-related homotopic FC increases were observed between left and right dorsal frontal-parietal regions. With regard to intra-hemispheric connections, recovery was dominated by increased ipsilateral connectivity between frontal and parietal regions along with decreased connectivity between the frontal regions and posterior parietal-occipital-temporal areas. Both inter and intra-hemispheric changes were associated with treatment-driven improvements in spelling performance. We suggest an interpretation according to which, with treatment, as posterior orthographic processing areas become more effective, executive control from frontal-parietal networks becomes less necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.