ArticleJornal de pediatria
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Mortality in children with cancer and SARS-CoV-2 in Latin America: A systematic review.Frontiers in pediatrics · 2022Pooled it
- The Spectrum of Antibiotic Prescribing During COVID-19 Pandemic: A Systematic Literature Review.Microbial drug resistance (Larchmont, N.Y.) · 2021Pooled it
- Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis.The American journal of emergency medicine · 2021Pooled it
- The inflammatory markers of multisystem inflammatory syndrome in children (MIS-C) and adolescents associated with COVID-19: A meta-analysis.Journal of medical virology · 2021Pooled it
- Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): a narrative review and the viewpoint of the Latin American Society of Pediatric Intensive Care (SLACIP) Sepsis Committee.BMJ paediatrics open · 2021Pooled it
- Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes.Jornal de pediatriaPooled it
- Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm.The Journal of pediatrics · 2026Article
- Meta-analysis on clinical manifestation and laboratory parameters of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C).Journal of family medicine and primary care · 2025Article
- Performance of Pediatric Risk of Mortality IV in Brazilian PICUs: A Multicenter Prospective Study.Critical care explorations · 2025Article
- Factors associated with the occurrence of COVID-19 in the pediatric population in hospital settings: a case-control study.Revista da Escola de Enfermagem da U S P · 2025Article
- Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2-Case Series of a Pediatric Intensive Care Unit in Portugal.Journal of pediatric intensive care · 2024Article
- Gastrointestinal and Hepatic Manifestations of COVID-19 in Children: A Systematic Review and Meta-analysis.Acta medica Philippina · 2024Article
- Analysis of factors associated with admission to the intensive care unit of children and adolescents with COVID-19: application of a multilevel model.Critical care science · 2024Article
- Factors Associated with Adverse Outcomes among SARS-CoV-2 Positive Children in a Tertiary Government COVID-19 Referral Hospital in the Philippines.Acta medica Philippina · 2024Article
- Infant COVID-19 Infection: An Experience from Pediatric Intensive Care Unit of a Tertiary Care Dedicated Pediatric COVID Hospital.Journal of pediatric intensive care · 2023Article
- Pediatric COVID-19: clinical and epidemiological data of 1303 cases in a general hospital in Brazil.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Article
- ICU Admission, Invasive Mechanical Ventilation, and Mortality among Children and Adolescents Hospitalized for COVID-19 in a Private Healthcare System.International journal of pediatrics · 2023Article
- Paediatric critical COVID-19 and mortality in a multinational prospective cohort.Lancet regional health. Americas · 2022Article
- Twelve Months with COVID-19: What Gastroenterologists Need to Know.Digestive diseases and sciences · 2022Review
- Critically Ill Pediatric Patient and SARS-CoV-2 Infection.Children (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
32 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19.
methodProspective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity.
resultsSeventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43-21.12; p = 0.01).
conclusionsIn Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.
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