ArticleThe clinical respiratory journal2020
Predictors for long-term mortality in COPD patients requiring non-invasive positive pressure ventilation for the treatment of acute respiratory failure.
Article in The clinical respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Prediction of one-year post-discharge mortality in patients with acute exacerbation of chronic obstructive pulmonary disease based on clinical characteristics, blood gas indicators, and duration of non-invasive ventilation.Journal of thoracic disease · 2026Article
- Factors Influencing Mechanical Ventilation and Inpatient Palliative Care Utilization in Patients With Chronic Obstructive Pulmonary Disease.Journal of multidisciplinary healthcare · 2025Article
- Long-term outcomes in patients with COPD treated with non-invasive ventilation for acute hypercapnic respiratory failure.Irish journal of medical science · 2024Article
- What Is the Potential Value of a Randomized Trial of Different Thresholds to Initiate Invasive Ventilation? A Health Economic Analysis.Critical care explorations · 2024Article
- Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients.ERJ open research · 2024Article
- Clinical practice of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.Respiratory research · 2023Article
- Acute COPD exacerbation treatment with noninvasive ventilation.Scientific reports · 2023Article
- Hypercapnic Failure in Acute Exacerbated COPD Patients: Severe Airflow Limitation as an Early Warning Signal.Journal of clinical medicine · 2022Article
- High-pressure NIV for acute hypercapnic respiratory failure in COPD: improved survival in a retrospective cohort study.BMJ open respiratory research · 2022Article
- Predictors for long-term mortality in COPD patients requiring non-invasive positive pressure ventilation for the treatment of acute respiratory failure.The clinical respiratory journal · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe effectiveness of non-invasive mechanical ventilation (NIV) in the management of COPD patients suffering from acute respiratory failure (ARF) as a consequence of exacerbation of the disease, is well established. However, data on long-term outcomes and their predictors, including the individual response to NIV, are scarce.
objectivesTo investigate predictors for short- and long-term mortality in this study population.
methodsA retrospective cohort study was performed including all patients admitted to the Medium Respiratory Care Unit of Maastricht University Medical Center in Maastricht, the Netherlands, with hospitalized exacerbation of COPD (H-ECOPD) with ARF requiring NIV for the first time between January 2009 and December 2011. An extensive number of potential predictors of outcomes, including the response to NIV, were determined on admission and during hospitalization. Univariate and multivariate logistic regression was used for statistical analysis.
resultsSeventy-eight consecutive patients with moderate to severe COPD (mean age 71.0 ± 10.7 years; 48.7% males) were included; In-hospital, 1-year and 2-year mortality rates were 14.1%, 43.6% and 56.4%, respectively. Independent risk factors for 2-year mortality were: advanced age (odds ratio(OR) 1.025; confidence interval (CI) 1.002-1.049; P = 0.037), prolonged NIV use more than 8 days (OR:1.054;CI:1.006-1.104; P = 0.027) and no successful response to NIV (OR:2.392;CI:1.297-4.413; P = 0.005).
conclusionPatients with an H-ECOPD requiring NIV for the first time, constitute a severely ill patient group with high in-hospital and 2-year mortality. This study identified advanced age, NIV use more than 8 days and unsuccessful response to NIV as clinical important independent predictors for long-term mortality.
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