Evidence map›Paper›PMID 32780691›Full record

ReviewJournal of sport and health science2020

Physical exercise in the prevention and treatment of Alzheimer's disease.

Adrian De la Rosa, Gloria Olaso-Gonzalez, Coralie Arc-Chagnaud, Fernando Millan, Andrea Salvador-Pascual, Consolacion García-Lucerga, Cristina Blasco-Lafarga, Esther Garcia-Dominguez, Aitor Carretero, Angela G Correas and 2 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of sport and health science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06740162 (A Stage 1 Pilot Test for Feasibility and Efficacy of a Multi-Level Intervention to Increase Physical Activity in Adults With Intellectual Disability), which is not on this map. Cited by 305 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06740162 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Stage 1 Pilot Test for Feasibility and Efficacy of a Multi-Level Intervention to Increase Physical Activity in Adults With Intellectual Disability: Physical Activity and Community EmPOWERment (PACE)

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2025 to 2028Enrolled376ConditionsIntellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down SyndromeArmsPACE Program
3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  6. Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  18. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
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245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adrian De la RosaFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Gloria Olaso-GonzalezFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Coralie Arc-ChagnaudFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain; INRA, UMR866 Muscle dynamics and metabolism, University of Montpellier, F-34060, Montpellier, France.
Fernando MillanFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Andrea Salvador-PascualFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Consolacion García-LucergaDepartment of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Valencia 46010, Spain.
Cristina Blasco-LafargaPhysical Education and Sports Department, University of Valencia, Valencia 46010, Spain.
Esther Garcia-DominguezFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Aitor CarreteroFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Angela G CorreasFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain.
Jose ViñaFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain. Electronic address: jose.vina@uv.es.
Mari Carmen Gomez-CabreraFreshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, and CIBERFES, Insitute of Health Research-INCLIVA, Valencia 46010, Spain. Electronic address: carmen.gomez@uv.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia is one of the greatest global challenges for health and social care in the 21st century. Alzheimer's disease (AD), the most common type of dementia, is by no means an inevitable consequence of growing old. Several lifestyle factors may increase, or reduce, an individual's risk of developing AD. Much has been written over the ages about the benefits of exercise and physical activity. Among the risk factors associated with AD is a low level of physical activity. The relationship between physical and mental health was established several years ago. In this review, we discuss the role of exercise (aerobic and resistance) training as a therapeutic strategy for the treatment and prevention of AD. Older adults who exercise are more likely to maintain cognition. We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies. We will pay especial attention to the potential role of exercise in the modulation of amyloid β turnover, inflammation, synthesis and release of neurotrophins, and improvements in cerebral blood flow. Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide. Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.

Indexed as

ExerciseExercise TherapyAgingAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCerebrovascular CirculationCognitionHealthy LifestyleHumansInflammationNerve Growth FactorsRisk Factorstau ProteinsAmyloid beta-PeptidesNerve Growth Factorstau ProteinsAerobic exerciseDementiaExercise trainingLifestyle factorsMultidomain interventionsResistance exercise

Identifiers

PMID32780691
PMCPMC7498620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.