Evidence map›Paper›PMID 32780493›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

SARS-CoV-2 infection and early mortality of waitlisted and solid organ transplant recipients in England: A national cohort study.

Rommel Ravanan, Chris J Callaghan, Lisa Mumford, Ines Ushiro-Lumb, Douglas Thorburn, John Casey, Peter Friend, Jayan Parameshwar, Ian Currie, Lisa Burnapp and 10 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 4 pooled it
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  2. COVID-19 and solid organ transplantation: Finding the right balance.Transplantation reviews (Orlando, Fla.) · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Observational
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  17. Kidney transplantation during mass disasters - from COVID-19 to other catastrophes A Consensus Statement by the DESCARTES Working Group and Ethics Committee of the ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  18. Review
  19. Review
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Rommel RavananChair, , Kidney Advisory Group, NHS Blood and Transplant, Bristol, UK.ORCID 0000-0003-3324-9024
Chris J CallaghanNational Clinical Lead for Abdominal Organ Utilisation, NHS Blood and Transplant, Bristol, UK.ORCID 0000-0003-3334-4152
Lisa MumfordStatistics and Clinical Studies, NHS Blood and Transplant, Bristol, UK.
Ines Ushiro-LumbLead Clinical Microbiologist, NHS Blood and Transplant, Bristol, UK.
Douglas ThorburnChair, Liver Advisory Group, NHS Blood and Transplant, Bristol, UK.
John CaseyChair, Pancreas Advisory Group, NHS Blood and Transplant, Bristol, UK.
Peter FriendChair, Multi-Visceral & Composite Tissue Advisory Group, NHS Blood and Transplant, Bristol, UK.
Jayan ParameshwarChair, Cardiothoracic Advisory Group, NHS Blood and Transplant, Bristol, UK.
Ian CurrieNational Clinical Lead for Organ Retrieval, NHS Blood and Transplant, Bristol, UK.ORCID 0000-0003-1636-6130
Lisa BurnappClinical Lead for Living Donation, NHS Blood and Transplant, Bristol, UK.
Richard BakerJoint National Clinical Lead for Governance, NHS Blood and Transplant, Bristol, UK.
Jan DudleyChair, Paediatric Sub-Group of the Kidney Advisory Group, NHS Blood and Transplant, Bristol, UK.
Gabriel C OniscuChair, Research Innovation and Novel Technologies Advisory Group, NHS Blood and Transplant, Bristol, UK.
Marius BermanAssociate National Clinical Lead for Organ Retrieval, NHS Blood and Transplant, Bristol, UK.
John AsherNational Clinical Lead for Health Informatics, NHS Blood and Transplant, Bristol, UK.
Dan HarveyNational Clinical Lead for Innovation & Research in Organ Donation, NHS Blood and Transplant, Bristol, UK.
Alex ManaraNational Quality Lead in Organ Donation, NHS Blood and Transplant, Bristol, UK.ORCID 0000-0002-0584-7222
Derek ManasJoint National Clinical Lead for Governance, NHS Blood and Transplant, Bristol, UK.
Dale GardinerNational Clinical Lead for Organ Donation, NHS Blood and Transplant, Bristol, UK.
John L R ForsytheMedical Director, NHS Blood and Transplant, Bristol, UK.
NHS Blood and Transplant · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients waitlisted for and recipients of solid organ transplants (SOT) are perceived to have a higher risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and death; however, definitive epidemiological evidence is lacking. In a comprehensive national cohort study enabled by linkage of the UK transplant registry and Public Health England and NHS Digital Tracing services, we examined the incidence of laboratory-confirmed SARS-CoV-2 infection and subsequent mortality in patients on the active waiting list for a deceased donor SOT and recipients with a functioning SOT as of February 1, 2020 with follow-up to May 20, 2020. Univariate and multivariable techniques were used to compare differences between groups and to control for case-mix. One hundred ninety-seven (3.8%) of the 5184 waitlisted patients and 597 (1.3%) of the 46 789 SOT recipients tested positive for SARS-CoV-2. Mortality after testing positive for SARS-CoV-2 was 10.2% (20/197) for waitlisted patients and 25.8% (154/597) for SOT recipients. Increasing recipient age was the only variable independently associated with death after positive SARS-CoV-2 test. Of the 1004 transplants performed in 2020, 41 (4.1%) recipients have tested positive for SARS-CoV-2 with 8 (0.8%) deaths reported by May 20. These data provide evidence to support decisions on the risks and benefits of SOT during the coronavirus disease 2019 pandemic.

Indexed as

Organ TransplantationPandemicsRegistriesSARS-CoV-2Tissue DonorsTransplant RecipientsAdolescentAdultChildChild, PreschoolCOVID-19EnglandFemaleHumansInfantInfant, Newborn

Identifiers

PMID32780493
PMCPMC7436919
OpenAlexW3047856909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.