Evidence map›Paper›PMID 32780290›Full record

ReviewApplied microbiology and biotechnology2020

The microbial coinfection in COVID-19.

Xi Chen, Binyou Liao, Lei Cheng, Xian Peng, Xin Xu, Yuqing Li, Tao Hu, Jiyao Li, Xuedong Zhou, Biao Ren

Open access · bronzeAbstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 2 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 2 syntheses or guidelines pooled it, 333 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  9. Co-infection models ofFrontiers in cellular and infection microbiology · 2026
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  11. Positivity analysis ofMicrobiology spectrum · 2025
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  16. Epidemiological and molecular study of Providencia rettgeri outbreak at a university hospital during the COVID-19 reference center.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xi ChenState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Binyou LiaoState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Lei ChengState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Xian PengState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Xin XuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Yuqing LiState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Tao HuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Jiyao LiState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Xuedong ZhouState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China. zhouxd@scu.edu.cn.
Biao RenState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China. renbiao@scu.edu.cn.ORCID http://orcid.org/0000-0003-4215-2873
Sichuan University · CN

Funding

Sichuan University 2020scunCoV-10008
6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS: • Microbial coinfection is a nonnegligible factor in COVID-19. • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. • Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.

Indexed as

PandemicsAnti-Bacterial AgentsAntiviral AgentsBacterial InfectionsBetacoronavirusCoinfectionCoronavirus InfectionsCOVID-19Cytokine Release SyndromeCytokinesDisease ProgressionHost-Pathogen InteractionsHumansImmunity, InnateLymphocytesLymphopeniaAnti-Bacterial AgentsAntiviral AgentsCytokinesCoinfectionCOVID-19MicroorganismSARS-CoV-2

Identifiers

PMID32780290
PMCPMC7417782
OpenAlexW3048494013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.