Evidence map›Paper›PMID 32780258›Full record

Trial reportObesity surgery2021

Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

Nathalia Ramori Farinha Wagner, Marilia Rizzon Zaparolli Ramos, Ligia de Oliveira Carlos, Magda Rosa Ramos da Cruz, Cesar Augusto Taconeli, Alcides José Branco Filho, Luis Sergio Nassif, Maria Eliana Madalozzo Schieferdecker, Antônio Carlos Ligocki Campos

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Review
  13. Review
  14. Current Trends in Gastric Cancer Surgery and Postoperative Care.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Review
  15. Observational
  16. Review
  17. Review
  18. Review
  19. [Research progress of probiotics regulating intestinal micro-ecological environment in obese patients after bariatric surgery].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nathalia Ramori Farinha WagnerNutrition Department (Nassif Clinic), Santa Casa de Misericórdia de Curitiba Hospital, Rua Bruno Filgueira, 485 - Batel, 80240-220,, Curitiba, Paraná, Brazil. nathalia_farinha@yahoo.con.br.ORCID http://orcid.org/0000-0003-0058-2859
Marilia Rizzon Zaparolli RamosClinical Surgery Department, Federal University of Parana, Curitiba, Brazil.
Ligia de Oliveira CarlosClinical Surgery Department, Federal University of Parana, Curitiba, Brazil.
Magda Rosa Ramos da CruzPontifical Catholic University of Paraná (PUCPR), Curitiba, Brazil.
Cesar Augusto TaconeliDepartment of Statistics, Federal University of Paraná, Curitiba, Brazil.
Alcides José Branco FilhoSanta Casa de Misericórdia de Curitiba Hospital, Curitiba, Brazil.
Luis Sergio NassifSanta Casa de Misericórdia de Curitiba Hospital, Curitiba, Brazil.
Maria Eliana Madalozzo SchieferdeckerNutrition Department, Federal University of Parana, Curitiba, Brazil.
Antônio Carlos Ligocki CamposClinical Surgery Department, Federal University of Parana, Curitiba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bariatric surgery may cause undesirable gastrointestinal symptoms due to anatomical, functional and intestinal microbiota changes. PURPOSE: The aim of this study was to evaluate the effect of probiotic supplementation on gastrointestinal symptoms and small intestine bacterial overgrowth (SIBO) in patients after Roux-en-Y gastric bypass (RYGB). MATERIALS AND

methodsThis is a prospective, randomized, double-blind, placebo-controlled trial. The patients were randomized into Control Group (CG) (n = 39) and Probiotic Group (PG) (n = 34). The PG received tablets containing Lactobacillus acidophilus and Bifidobaterium lactis (5 billion CFU/strain) for 90 days, and the CG received tablets with starch. Both the Gastric Symptom Rating Scale (GSRS) questionnaire and 3-day food record were answered before surgery (T0) and after 45 days (T1) and 90 days of surgery (T2). At T0 and T2, hydrogen breath test was used to verify the presence of SIBO.

resultsThe prevalence of SIBO was similar among times, and the mean score of GSRS responses did not differ between groups at any time. However, PG patients reported less bloating compared to CG, more abdominal pain at T1 (which reduced at T2), more episodes of soft stools and nausea and less hunger pain after surgery, with no reports of urgent episodes to evacuate, even though they consumed more fat than the CG.

conclusionsThe supplementation of L. acidophilus and B. lactis is effective in reducing bloating, but without influencing the development of SIBO in the early postoperative period.

Indexed as

Gastric BypassGastrointestinal MicrobiomeObesity, MorbidProbioticsDouble-Blind MethodHumansProspective StudiesBariatric surgeryGastrointestinal symptomsProbiotics

Identifiers

PMID32780258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.