ArticleNaunyn-Schmiedeberg's archives of pharmacology2021
Gastric healing effect of p-coumaric acid isolated from Baccharis dracunculifolia DC on animal model.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Anxiolytic-like effects of p-coumaric acid via GABAergic interaction pathways: an in vivo and in silico study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Phytochemical Analysis and Antioxidant Activities ofAntioxidants (Basel, Switzerland) · 2025Article
- Effects ofPharmaceutics · 2024Article
- Article
- P-coumaric Acid: Advances in Pharmacological Research Based on Oxidative Stress.Current topics in medicinal chemistry · 2024Review
- Phenolic Compounds in Fractionated Blackcurrant Leaf Extracts in Relation to the Biological Activity of the Extracts.Molecules (Basel, Switzerland) · 2023Article
- The GenusFrontiers in pharmacology · 2022Review
- Ethnomedicinal, phytochemical and pharmacological investigations ofFrontiers in pharmacology · 2022Review
- Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review.Pharmaceutics · 2021Review
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p-coumaric acid is a phenolic compound present in large quantities in the extract of Baccharis dracunculifolia DC, a Brazilian medicinal plant used to treat gastric ulcer. Given the necessity for finding new chemical components capable of accelerating gastric healing, in this study, the effects of the p-coumaric acid were evaluated in the acetic acid-induced ulcer model in rats, where histological, inflammatory, and oxidative parameters were analyzed. The healing property was also evaluated in the scratch assay on fibroblast cells (L929) and the cytotoxicity of p-coumaric acid was assessed in both L929 and human gastric adenocarcinoma (AGS) cells by MTT assay. The treatment with p-coumaric acid (10 mg/kg, p.o.) for 7 days, twice a day, decreased by 44.6% the acetic acid-induced gastric ulcer compared with the vehicle-treated group. The vehicle control-treated group showed a larger extension of the ulcer base and an extensive damage into the mucosa and submucosa layers, which were mitigated by the treatment with p-coumaric acid. This beneficial effect was also associated with increased levels of mucin and reduced glutathione, decreased amount of lipid hydroperoxides, and increased superoxide dismutase and catalase activities without interfering with the activity of myeloperoxidase in the gastric tissue. The compound promoted the restructuring of the cell monolayer in the scratch test and did not show toxicity in the L929 cell line, while reduced the viability of the AGS, a lineage of human gastric adenocarcinoma. Thus, p-coumaric acid may be considered a natural source for the treatment of gastric ulcers, by reinforcing protective factors of gastric mucosa and by accelerating gastric healing.
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