← Metformin × adverse events & safety

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Association between combined treatment with SGLT2 inhibitors and metformin for type 2 diabetes mellitus on fracture risk: a meta-analysis of randomized controlled trials.

B-B Qian et al.PubMed ↗Publisher ↗

What the trial testedas reported · 19,500 people · 2020

Range includes no effect

No clear effect on adverse events & safety

−3%−29% to +32%

Bigger than 1 in 10 for adverse events & safety

As reported

OR 0.97, 95% CI 0.71–1.32

One number in the abstract

the abstract, start to end

… comparators in patients with T2DM (OR = 0.97, 95% CI 0.71-1.32).

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
OR 0.970.71–1.32
MetforminSGLT2 inhibitorsAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 32780153