ArticleRadiology2020
Emphysema Index Based on Hyperpolarized
Abstract readComparative Study
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Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24citing papers in PubMed, 1 pooled it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Imaging endpoints for biologic therapy in chronic obstructive pulmonary disease.The British journal of radiology · 2026Review
- Magnetic Resonance Imaging in the Clinical Evaluation of Lung Disorders: Current Status and Future Prospects.Journal of magnetic resonance imaging : JMRI · 2025Review
- Article
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Loss of pulmonary capillaries in idiopathic pulmonary arterial hypertension with low diffusion capacity is accompanied by early diffuse emphysema detected byEuropean radiology · 2025Observational
- Article
- UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Imaging Brown Adipose Tissue: Current State and Future Perspective.Theranostics · 2025Review
- Improved Diffusion-Weighted HyperpolarizedAcademic radiology · 2024Article
- Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarizedJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024Article
- Voxel-Wise Comparison of Co-Registered Quantitative CT and Hyperpolarised Gas Diffusion-Weighted MRI Measurements in IPF.Diagnostics (Basel, Switzerland) · 2023Article
- MR imaging of the airways.The British journal of radiology · 2023Review
- Targeted Imaging of Lung Cancer with HyperpolarizedCancers · 2022Article
- Lung MRI with hyperpolarised gases: current & future clinical perspectives.The British journal of radiology · 2022Review
- Functional imaging of COPD by CT and MRI.The British journal of radiology · 2022Article
- State-of-the-art MR Imaging for Thoracic Diseases.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Review
- Accelerate gas diffusion-weighted MRI for lung morphometry with deep learning.European radiology · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Sina TaftiFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-6239-2906
William J GarrisonFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-2080-5987
John P MuglerFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-4140-308X
Y Michael ShimFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).
Talissa A AltesFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-8969-8673
Jaime F MataFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-2274-1470
Eduard E de LangeFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-1473-5986
Gordon D CatesFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).
Alan M RoppFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0003-3608-0965
Chengbo WangFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0001-9779-4713
G Wilson MillerFrom the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).ORCID 0000-0002-4833-8321
Funding
Hyperpolarized Xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeuticsR01HL132177 · NHLBI · UNIVERSITY OF VIRGINIA · PI QING, KUN, SHIM, YUN MICHAEL · 2017 to 2021
$3.9MRegional Quantification of Lung Function in Cystic Fibrosis using Xe129 MRIR01CA172595 · NCI · UNIVERSITY OF VIRGINIA · PI MATA, JAIME · 2013 to 2017
$1.6MOptimization of Hyperpolarized Xenon-129 Diffusion MRI for COPDR01HL105586 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, G. WILSON, WANG, CHENGBO · 2011 to 2015
$1.5MHigh-Performance Xe129 Gas Polarization System for MR ImagingS10OD018079 · OD · UNIVERSITY OF VIRGINIA · PI MATA, JAIME · 2014 to 2014
$600kNCI NIH HHS R01 CA172595NHLBI NIH HHS R01 HL105586NHLBI NIH HHS R01 HL132177NIH HHS S10 OD018079
Abstract
Background Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases have shown promise in the characterization of emphysema in patients with chronic obstructive pulmonary disease (COPD), yet an easily interpreted quantitative metric beyond mean and standard deviation has not been established. Purpose To introduce a quantitative framework with which to characterize emphysema burden based on hyperpolarized helium 3 (
Indexed as
Case-Control StudiesDiffusion Magnetic Resonance ImagingFemaleHeliumHumansMaleMiddle AgedPulmonary EmphysemaRespiratory Function TestsTomography, X-Ray ComputedXenon IsotopesHeliumXenon-129Xenon Isotopes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.