Evidence map›Paper›PMID 32779889›Full record

ArticleJournal of cellular and molecular medicine2020

Malaria in pregnancy regulates P-glycoprotein (P-gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac.

Lilian M Martinelli, Klaus N Fontes, Mila W Reginatto, Cherley B V Andrade, Victoria R S Monteiro, Hanailly R Gomes, Joao L Silva-Filho, Ana A S Pinheiro, Annamaria R Vago, Fernanda R C L Almeida and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Regulation of Placental Efflux Transporters during Pregnancy Complications.Drug metabolism and disposition: the biological fate of chemicals · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Lilian M MartinelliDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Klaus N FontesLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mila W ReginattoLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Cherley B V AndradeLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Victoria R S MonteiroLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Hanailly R GomesLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Joao L Silva-FilhoLaboratory of Immunology and Biochemistry of Parasitic Diseases, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ana A S PinheiroLaboratory of Immunology and Biochemistry of Parasitic Diseases, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Annamaria R VagoDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Fernanda R C L AlmeidaDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Flavia F BloiseLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Stephen G MatthewsDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Tania M Ortiga-CarvalhoLaboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-0225-1132
Enrrico BloiseDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0003-0275-8686
Universidade Federal do Rio de Janeiro · BRUniversidade Federal de Minas Gerais · BRMount Sinai Hospital · CA

Funding

Bill & Melinda Gates Foundation OPP1107597CIHR Foundation-148368
6 · The paper itself

Abstract

Malaria in pregnancy (MiP) induces intrauterine growth restriction (IUGR) and preterm labour (PTL). However, its effects on yolk sac morphology and function are largely unexplored. We hypothesized that MiP modifies yolk sac morphology and efflux transport potential by modulating ABC efflux transporters. C57BL/6 mice injected with Plasmodium berghei ANKA (5 × 10

Indexed as

Gene Expression RegulationAnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily BBiological TransportCytokinesFemaleFetal Growth RetardationInflammationMalariaMembrane Transport ProteinsMiceMice, Inbred C57BLOrgan SizePlasmodium bergheiPregnancyAbca1 protein, mouseATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily BCytokinesMembrane Transport Proteinsmultidrug resistance protein 3RNA, MessengerABCA1ABCG1Breast Cancer Resistance Protein (BCRP)malaria in pregnancy (MiP)P-glycoprotein (P-gp)Plasmodium berghei ANKAyolk sac

Identifiers

PMID32779889
PMCPMC7521277
OpenAlexW3048555725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.