ArticleHuman brain mapping2020
Functional dissection of prenatal drug effects on baby brain and behavioral development.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.Neuroradiology · 2025Pooled it
- Systematic review: the impact of maternal pre-and postnatal cannabis use on the behavioral and emotional regulation in early childhood.European child & adolescent psychiatry · 2025Pooled it
- A coordinate-based meta-analysis of human amygdala connectivity alterations related to early life adversities.Scientific reports · 2023Pooled it
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Article
- Neurodevelopmental outcomes following prenatal cannabinoid exposure: a systematic review.European child & adolescent psychiatry · 2026Review
- Investigating Links Between Prenatal Cannabis Exposure and Brain Development Using Magnetic Resonance Imaging Techniques: A Narrative Review.Biological psychiatry global open science · 2026Review
- Anxiety, Depression, and Emotional Dysregulation Following Prenatal Substance Exposure.Advances in experimental medicine and biology · 2026Review
- A hierarchical model of early brain functional network development.Trends in cognitive sciences · 2025Review
- Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies.Frontiers in human neuroscience · 2025Review
- Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.Current topics in behavioral neurosciences · 2025Review
- Fetal behavior and gestational serotonin reuptake inhibitor exposure: relationships between behavior, drug dosage, plasma drug level, and a measure of drug bioeffect.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Impact of prenatal marijuana exposure on adolescent brain structural and functional connectivity and behavioural outcomes.Brain communications · 2024Article
- Genetic and environmental factors influencing neonatal resting-state functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Prenatal Selective Serotonin Reuptake Inhibitor Exposure, Depression, and Brain Morphology in Middle Childhood: Results From the ABCD Study.Biological psychiatry global open science · 2023Article
- Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice.Frontiers in behavioral neuroscience · 2023Article
- Thalamocortical functional connectivity in infants with prenatal opioid exposure correlates with severity of neonatal opioid withdrawal syndrome.Neuroradiology · 2022Article
- Evidence for the Normalization Effects of Medication for Opioid Use Disorder on Functional Connectivity in Neonates with Prenatal Opioid Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure.Frontiers in pediatrics · 2022Article
- Functional dissection of prenatal drug effects on baby brain and behavioral development.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Prenatal drug exposure (PDE) is known to affect fetal brain development with documented long-term consequences. Most studies of PDE effects on the brain are based on animal models. In this study, based on a large sample of 133 human neonates and leveraging a novel linear mixed-effect model designed for intersubject variability analyses, we studied the effects of six prenatally exposed drugs (i.e., nicotine, alcohol, selective serotonin reuptake inhibitor, marijuana, cocaine, and opioids) on neonatal whole-brain functional organization and compared them with five other critical nondrug variables (i.e., gestational age at birth/scan, sex, birth weight, and maternal depression). The behavioral implications were also examined. Magnitude-wise, through summing across individual drug effects, our results highlighted ~5% of whole-brain functional connections (FCs) affected by PDE, which was highly comparable with the combined effects of the five nond rug variables. Spatially, the detected PDE effects featured drug-specific patterns with a common bias in higher-order brain regions/networks. Regarding brain-behavioral relationships, the detected connections showing significant drug effects also demonstrated significant correlations with 3-month behavioral outcomes. Further mediation analyses supported a mediation role of the detected brain FCs between PDE status and cognitive/language outcomes. Our findings of widespread, and spatially biased PDE effect patterns coupled with significant behavioral implications may hopefully stimulate more human-based studies into effects of PDE on long-term developmental outcomes.
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