ArticleThe British journal of dermatology2021
The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series.
Article in The British journal of dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
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59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Epidemiology and clinical evolution of non-multisystem inflammatory syndrome (MIS-C) dermatological lesions in pediatric patients affected by SARS-CoV-2 infection: A systematic review of the literature.European journal of pediatrics · 2022Pooled it
- COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells.Seminars in immunopathology · 2022Pooled it
- Chilblain-Like Lesions (CLL) Coinciding With the SARS-CoV-2 Pandemic in Children: A Systematic Review.Journal of cutaneous medicine and surgeryPooled it
- Adenosine deaminase acting on RNA1 mutation in chilblain lupus treated with tofacitinib.JAAD case reports · 2026Article
- Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains.The Journal of experimental medicine · 2025Article
- Cutaneous Manifestations of COVID-19: A Descriptive Analysis of a Southeastern USA Purposive Sample.International wound journal · 2025Article
- Diagnosis and management of COVID toes in outpatients: a case report.Journal of medical case reports · 2024Article
- Emerging role of complement in COVID-19 and other respiratory virus diseases.Cellular and molecular life sciences : CMLS · 2024Review
- A curious case of 'COVID toes' in pregnancy.Obstetric medicine · 2023Article
- Microvascular C5b-9 deposition in non-lesional skin in patients with SLE and its correlation with active lupus nephritis: a prospective observational study.Lupus science & medicine · 2023Observational
- Part II: Cutaneous manifestations of peripheral vascular disease.Journal of the American Academy of Dermatology · 2023Review
- Levamisole-induced and COVID-19-induced retiform purpura: two overlapping, emerging clinical syndromes.Archives of dermatological research · 2023Review
- Functionality of immune cells in COVID-19 infection: development of cell-based therapeutics.BioImpacts : BI · 2023Review
- Abnormal thrombosis and neutrophil activation increase hospital-acquired sacral pressure injuries and morbidity in COVID-19 patients.Frontiers in immunology · 2023Article
- A case of late ulceration of infantile hemangioma in the setting of SARS-CoV2 infection.JAAD case reports · 2023Article
- Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage.The American journal of pathology · 2022Article
- Purple toes following critical COVID-19 infection.Pediatric dermatology · 2022Article
- Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches.The Journal of clinical investigation · 2022Review
- Dermatological Manifestations of COVID-19 in Children.Indian pediatrics · 2022Review
- Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydrochloride.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Review
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8 authors at 6 institutions in 1 country.
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Abstract
backgroundThere are two distinctive acral manifestations of COVID-19 embodying disparate clinical phenotypes. One is perniosis occurring in mildly symptomatic patients, typically children and young adults; the second is the thrombotic retiform purpura of critically ill adults with COVID-19.
objectivesTo compare the clinical and pathological profiles of these two different cutaneous manifestations of COVID-19.
methodsWe compared the light microscopic, phenotypic, cytokine and SARS-CoV-2 protein and RNA profiles of COVID-19-associated perniosis with that of thrombotic retiform purpura in critical patients with COVID-19.
resultsBiopsies of COVID-19-associated perniosis exhibited vasocentric and eccrinotropic T-cell- and monocyte-derived CD11c
conclusionsCOVID-19-associated perniosis represents a virally triggered exaggerated immune reaction with significant type I interferon signaling. This is important to SARS-CoV-2 eradication and has implications in regards to a more generalized highly inflammatory response. We hypothesize that in the thrombotic retiform purpura of critically ill patients with COVID-19, the vascular thrombosis in the skin and other organ systems is associated with a minimal interferon response. This allows excessive viral replication with release of viral proteins that localize to extrapulmonary endothelium and trigger extensive complement activation.
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