ArticleJornal brasileiro de nefrologia
Case reports of hypercalcemia and chronic renal disease due to cosmetic injections of polymethylmethacrylate (PMMA).
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Hypercalcemia and Renal Complications Following High-Volume Polymethyl Methacrylate (PMMA) Injections: A Case Series.Aesthetic plastic surgery · 2025Observational
- A Comprehensive Review of Electrolyte Imbalances and Their Applied Aspects in Dermatology.Cureus · 2025Review
- Treatment of hypercalcemia related to polymethylmethacrylate injection: report of three cases.Einstein (Sao Paulo, Brazil) · 2025Article
- Biopolymers: Histopathologic Case Series of Patients with Permanent Synthetic Fillers Presenting Chronic Granulomatous Reaction and Hypercalcemia.Plastic and reconstructive surgery. Global open · 2024Article
- Endocrine Shades of Silicone Fillers: A Case of Calcitriol-mediated Hypercalcemia.Journal of community hospital internal medicine perspectives · 2024Article
- Safety and Efficiency of Minimally Invasive Buttock Augmentation: A Review.Aesthetic plastic surgery · 2023Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cosmetic injections of fillers are common plastic surgery procedures worldwide. Polymethylmethacrylate (PMMA) is a filler approved only for minimally invasive procedures in facial tissue and is among the most frequently used injectable substances for cosmetic purposes. Injection of a large volume of PMMA may lead to the development of severe hypercalcemia and chronic kidney damage in a probably underestimated frequency. In such cases, hypercalcemia develops due to a granulomatous foreign body reaction with extrarenal production of calcitriol. In the present report, we describe the cases of two patients who received injections of large volumes of PMMA and developed severe hypercalcemia and advanced chronic kidney disease. These reports highlight the importance of adhering to regulations regarding the use of PMMA and properly informing patients of the possibility of complications before undertaking such procedures.
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