ArticleLab on a chip2020
Acoustofluidic multi-well plates for enrichment of micro/nano particles and cells.
Article in Lab on a chip, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Coupling Agents in Acoustofluidics: Mechanisms, Materials, and Applications.Micromachines · 2025Review
- Sound innovations for biofabrication and tissue engineering.Microsystems & nanoengineering · 2024Review
- Capillary-based, multifunctional manipulation of particles and fluidsJournal of physics D: Applied physics · 2024Article
- Open and closed microfluidics for biosensing.Materials today. Bio · 2024Review
- Robot-assisted chirality-tunable acoustic vortex tweezers for contactless, multifunctional, 4-DOF object manipulation.Science advances · 2024Article
- Herbicide Bioassay Using a Multi-Well Plate and Plant Spectral Image Analysis.Sensors (Basel, Switzerland) · 2024Article
- Study on the Cooling Performance of a Focused Ultrasonic Radiator for Electrical Heating Elements.Micromachines · 2024Article
- Acoustofluidic scanning fluorescence nanoscopy with a large field of view.Microsystems & nanoengineering · 2024Article
- Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator.Microsystems & nanoengineering · 2024Article
- Acoustofluidic Interfaces for the Mechanobiological Secretome of MSCs.Nature communications · 2023Article
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- Microparticle Manipulation Based on the Bulk Acoustic Wave Combined with the Liquid Crystal Backflow Effect Driving in 2D/3D Platforms.ACS omega · 2022Article
- Acoustofluidic black holes for multifunctional in-droplet particle manipulation.Science advances · 2022Article
- Concentration of Microparticles Using Flexural Acoustic Wave in Sessile Droplets.Sensors (Basel, Switzerland) · 2022Article
- [Research progress in the application of external field separation technology and microfluidic technology in the separation of micro/nanoscales].Se pu = Chinese journal of chromatography · 2021Review
- Acoustofluidic localization of sparse particles on a piezoelectric resonant sensor for nanogram-scale mass measurements.Microsystems & nanoengineering · 2021Article
- Microfluidic High-Throughput Platforms for Discovery of Novel Materials.Nanomaterials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Controllable enrichment of micro/nanoscale objects plays a significant role in many biomedical and biochemical applications, such as increasing the detection sensitivity of assays, or improving the structures of bio-engineered tissues. However, few techniques can perform concentrations of micro/nano objects in multi-well plates, a very common laboratory vessel. In this work, we develop an acoustofluidic multi-well plate, which adopts an array of simple, low-cost and commercially available ring-shaped piezoelectric transducers for rapid and robust enrichment of micro/nanoscale particles/cells in each well of the plate. The enrichment mechanism is validated and characterized through both numerical simulations and experiments. We observe that the ring-shaped piezoelectric transducer can generate circular standing flexural waves in the substrate of each well, and that the vibrations can induce acoustic streaming near the interface between the substrate and a fluid droplet placed within the well; this streaming can drive micro/nanoscale objects to the center of the droplet for enrichment. Moreover, the acoustofluidic multi-well plate can realize simultaneous and consistent enrichment of biological cells in each well of the plate. With merits such as simplicity, controllability, low cost, and excellent compatibility with other downstream analysis tools, the developed acoustofluidic multi-well plate could be a versatile tool for many applications such as micro/nano fabrication, self-assembly, biomedical/biochemical sensing, and tissue engineering.
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Registered trials
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