Evidence map›Paper›PMID 32779113›Full record

SynthesisInternal and emergency medicine2021

TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis.

Luigina Guasti, Silvia Galliazzo, Marta Molaro, Eleonora Visconti, Benedetta Pennella, Giovanni Vincenzo Gaudio, Alessandro Lupi, Anna Maria Grandi, Alessandro Squizzato

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Internal and emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 8 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 8 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Luigina GuastiDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy.
Silvia GalliazzoInternal Medicine Unit, Ospedale S.Valentino, Montebelluna, Treviso, Italy.
Marta MolaroOspedale Metropolitano Niguarda, Milan, Italy.
Eleonora ViscontiDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy.
Benedetta PennellaDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy.
Giovanni Vincenzo GaudioDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy.
Alessandro LupiDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy.
Anna Maria GrandiDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy.
Alessandro SquizzatoDepartment of Medicine and Surgery, University of Insubria, Varese, Como, Italy. alessandro.squizzato@uninsubria.it.
University of Insubria · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Socio Sanitaria Territoriale Lariana · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnmasking the residual cardiovascular risk is a major research challenge in the attempt to reduce cardiovascular disease (CVD) morbidity and mortality. Mounting evidence suggests that a high circulating level of trimethylamine N-oxide is a new potential CVD risk factor. We performed a systematic review of the published studies to clarify the association between circulating high levels of TMAO and cardiovascular events.

methodsStudies evaluating the association between TMAO and CVD events were searched by electronic databases up to December 2018. Pooled results were expressed as risk ratio (RR) with 95% pertinent confidence interval (CI).

resultsThree studies for a total of 923 patients at high/very high CVD risk were included in our analysis. Overall, a high TMAO level was associated with both major adverse cardiovascular events (RR = 2.05; 95% CI 1.61-2.61) and all-cause mortality (RR = 3.42; 95% CI 2.27-5.15).

conclusionsOur findings support a role of high TMAO levels in predicting CVD events. High levels of TMAO may be a new CVD risk factor, potentially useful to better plan personalized CVD prevention strategies.

Indexed as

BiomarkersCardiovascular DiseasesHumansMethylaminesRisk FactorsBiomarkersMethylaminestrimethyloxamineCardiovascular eventsGut microbiotaTrimethylamine oxide

Identifiers

PMID32779113
OpenAlexW3048872973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.