ReviewJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2021
Peripherally Acting μ-Opioid Receptor Antagonists in the Management of Postoperative Ileus: a Clinical Review.
Review in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Efficacy and safety of postoperative chewing gum for gastrointestinal recovery in children undergoing surgery: an updated systematic review and meta-analysis.Surgery today · 2026Pooled it
- Selective Opioid Antagonists Following Bowel Resection for Prevention of Postoperative Ileus: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Pooled it
- Postoperative continuous infusion of dexmedetomidine does not improve gastrointestinal function recovery after laparoscopic colorectal surgery: A randomized clinical trial.The Journal of international medical research · 2026Trial
- Impact of intravenous dexmedetomidine on gastrointestinal function recovery after laparoscopic hysteromyomectomy: a randomized clinical trial.Scientific reports · 2022Trial
- Dexmedetomidine and Postoperative Gastrointestinal Recovery: A Critical Narrative Review of Direct Enteric and Opioid-Sparing Pathways.Drug design, development and therapy · 2026Review
- Pathophysiological mechanisms, diagnostic innovations, and multimodal therapeutic strategies for slow transit constipation.BMC gastroenterology · 2025Review
- Review
- The impact of opioid administration on the incidence of postanaesthetic colic in horses.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Nomogram for predicting prolonged postoperative ileus after laparoscopic low anterior resection for rectal cancer.World journal of surgical oncology · 2023Article
- Predictive modeling of postoperative gastrointestinal dysfunction: the role of serum bilirubin, sodium levels, and surgical duration in gynecological cancer care.BMC women's health · 2023Article
- Management of Constipation in Hospitalized Patients.Journal of clinical medicine · 2023Review
- Incidence and Risk Factors for Postoperative Ileus after Posterior Surgery in Adolescent Idiopathic Scoliosis.Orthopaedic surgery · 2023Article
- Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis.Pain medicine (Malden, Mass.) · 2023Article
- Ileus rate after abdominal wall reconstruction: a retrospective analysis of two clinical trials.Hernia : the journal of hernias and abdominal wall surgery · 2022Review
- Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?Current oncology reports · 2022Review
- Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects.Nature communications · 2022Article
- State-of-the-art colorectal disease: postoperative ileus.International journal of colorectal disease · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative ileus (POI) and constipation are common secondary effects of opioids and carry significant clinical and economic impacts. μ-Opioid receptors mediate opioid analgesia in the central nervous system (CNS) and gastrointestinal-related effects in the periphery. Peripherally acting μ-opioid receptor antagonists (PAMORAs) block the peripheral effects of opioids in the gastrointestinal tract, while maintaining opioid analgesia in the CNS. While most are not approved for POI or postoperative opioid-induced constipation (OIC), PAMORAs have a potential role in these settings via their selective effects on the μ-opioid receptor. This review will discuss recent clinical trials evaluating the safety and efficacy of PAMORAs, with a focus on alvimopan (Entereg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.