ArticleThe American journal of clinical nutrition2020
Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies.
Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The association between dietary fiber intake and risk of lung cancer: a GRADE-assessed systematic review and dose response meta-analysis of prospective cohort studies.Nutrition journal · 2026Pooled it
- Anti-inflammatory Diet Index and Bladder Cancer Risk by Stage: A 22-Year Prospective Swedish Cohort Study (1998-2020).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Sex-specific effects of cereal-based diets on longevity and healthspan in Drosophila melanogaster.Biogerontology · 2026Article
- Intersection of Precision Nutrition and Bladder Cancer: A Narrative State-of-the-Art Review of Potential Applications and Challenges.Journal of clinical medicine · 2026Review
- Overview of tumor-resident intratumoral microbiota in human bladder cancer.Translational andrology and urology · 2026Article
- Grains, Cereals, and Legumes: Implications in Glycemic Index and Perspectives.Foods (Basel, Switzerland) · 2025Article
- Nutritional and Chemical Characterization of Red and Purple Potatoes Peels: A Polyphenol-Rich By-Product.Foods (Basel, Switzerland) · 2025Article
- Mapping the Quantitative Dose-Response Relationships Between Nutrients and Health Outcomes to Inform Food Risk-Benefit Assessment.Foods (Basel, Switzerland) · 2025Review
- The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer.Nature reviews. Microbiology · 2025Review
- Association of whole grain food consumption with lung cancer risk: a prospective cohort study.Cancer cell international · 2025Article
- Dietary fiber consumption and outcomes of different cancers: an umbrella review.Food & nutrition research · 2025Article
- Carcinogen metabolism and bladder cancer: role of gut microbiota in disease and prevention.Frontiers in cellular and infection microbiology · 2025Review
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- Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets.Signal transduction and targeted therapy · 2024Review
- Metabolic changes in response to varying whole-grain wheat and rye intake.NPJ science of food · 2024Article
- Diet Quality and Subsequent Incidence of Upper Gastrointestinal Cancers: Results from the Golestan Cohort Study.Archives of Iranian medicine · 2023Article
- Relationship between Bladder Cancer, Nutritional Supply, and Treatment Strategies: A Comprehensive Review.Nutrients · 2023Review
- Article
- Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer.Cancer discovery · 2022Article
Corrections and comments
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Authors and funding
17 authors at 10 institutions in 8 countries.
Funding
Abstract
backgroundHigher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer.
objectivesBecause the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber.
methodsWe pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC. HRs, with corresponding 95% CIs, were estimated using Cox regression models stratified on cohort. Dose-response relations were examined using fractional polynomial regression models.
resultsWe found that higher intake of total whole grain was associated with lower risk of BC (comparing highest with lowest intake tertile: HR: 0.87; 95% CI: 0.77, 0.98; HR per 1-SD increment: 0.95; 95% CI: 0.91, 0.99; P for trend: 0.023). No association was observed for intake of total refined grain. Intake of total dietary fiber was also inversely associated with BC risk (comparing highest with lowest intake tertile: HR: 0.86; 95% CI: 0.76, 0.98; HR per 1-SD increment: 0.91; 95% CI: 0.82, 0.98; P for trend: 0.021). In addition, dose-response analyses gave estimated HRs of 0.97 (95% CI: 0.95, 0.99) for intake of total whole grain and 0.96 (95% CI: 0.94, 0.98) for intake of total dietary fiber per 5-g daily increment. When considered jointly, highest intake of whole grains with the highest intake of dietary fiber showed 28% reduced risk (95% CI: 0.54, 0.93; P for trend: 0.031) of BC compared with the lowest intakes, suggesting potential synergism.
conclusionsHigher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly. Further studies are needed to clarify the underlying mechanisms for these findings.
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