ArticleNature biotechnology2021
Imaging volumetric dynamics at high speed in mouse and zebrafish brain with confocal light field microscopy.
Article in Nature biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 158 citations in OpenAlex.
- From barrier to guide: Exploiting disease-specific hemodynamics for enhanced nanodrug targeting in cardiovascular diseases.Pharmaceutical science advances · 2026Review
- Rapid robust high-fidelity 3D neuronal extraction from multiview calcium imaging datasets.Nature methods · 2026Article
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- Voltage imaging of neurons distributed across entire brains of larval zebrafish.Nature methods · 2026Article
- Graph-based modeling of optical system enables adaptive optics on dynamic samples with self-calibration.iScience · 2026Article
- Structured illumination microscopy for high SNR 3D imaging from millimeter-thick tissues to cellular dynamics.Innovation (Cambridge (Mass.)) · 2026Article
- A versatile platform for two-photon neuronal population voltage imaging across cortical depths.Nature methods · 2026Article
- Chromatix: a differentiable, GPU-accelerated wave-optics library.Nature methods · 2026Article
- Real-time robust autofocus method enabling sustained intravital scanning light field imaging.Nature communications · 2026Article
- Fast 3D dynamic visualization of porcine spermatozoa by using high-resolution wavefront coding light sheet microscopy and machine learning.Scientific reports · 2026Article
- High-speed whole-brain imaging in Drosophila.Nature communications · 2026Article
- High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics.Nature biotechnology · 2026Article
- Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull.Nature communications · 2026Article
- Chromatix: a differentiable, GPU-accelerated wave-optics library.bioRxiv : the preprint server for biology · 2026Article
- Super-resolution functional photoacoustic microscopy via label-free cell tracking.Light, science & applications · 2026Article
- Improved 3D image reconstruction via deep-learning-based fusion of light-field microscopy and Fourier light-field microscopy images.Journal of biomedical optics · 2026Article
- Intravital mesoscale optical imaging: challenges, techniques, and future perspectives.Biophysics reports · 2026Article
- Microvascular architecture and physiological fluctuations constrain the control of cerebral microcirculation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A modular tissue-clearing framework integrated with light-field microscopy enables rapid volumetric phenotyping of cardiac tissue.Research square · 2026Article
- Snapshot 3D at the speed frontier: redefining light-field microscopy for neuroimaging.PhotoniX · 2026Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A detailed understanding of the function of neural networks and how they are supported by a dynamic vascular system requires fast three-dimensional imaging in thick tissues. Here we present confocal light field microscopy, a method that enables fast volumetric imaging in the brain at depths of hundreds of micrometers. It uses a generalized confocal detection scheme that selectively collects fluorescent signals from the in-focus volume and provides optical sectioning capability to improve imaging resolution and sensitivity in thick tissues. We demonstrate recording of whole-brain calcium transients in freely swimming zebrafish larvae and observe behaviorally correlated activities in single neurons during prey capture. Furthermore, in the mouse brain, we detect neural activities at depths of up to 370 μm and track blood cells at 70 Hz over a volume of diameter 800 μm × thickness 150 μm and depth of up to 600 μm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.