ArticleScientific reports2020
Mass spectrometry imaging as a potential technique for diagnostic of Huanglongbing disease using fast and simple sample preparation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Analysis of Differential Metabolites in Citrus Leaves Infected with Huanglongbing and Screening of Biomarkers for Early Detection.Molecules (Basel, Switzerland) · 2026Article
- Resolving subcellular sucrose concentrations in plant tissues.Journal of experimental botany · 2026Review
- Targeted gene expression and associated metabolomic insights into Bacillus subtilis LBS5-mediated suppression of Candidatus liberibacter asiaticus in acid lime (Citrus aurantiifolia (christm.) swingle).World journal of microbiology & biotechnology · 2026Article
- Review
- Longitudinal Transcriptomic, Proteomic, and Metabolomic Response ofJournal of proteome research · 2024Article
- Identification of Plant Compounds with Mass Spectrometry Imaging (MSI).Metabolites · 2024Review
- Imaging plant metabolism in situ.Journal of experimental botany · 2024Review
- A Metabolomics Assay to Diagnose Citrus Huanglongbing Disease and to Aid in Assessment of Treatments to Prevent or Cure Infection.Phytopathology · 2024Article
- Mass Spectrometry Imaging for Spatial Chemical Profiling of Vegetative Parts of Plants.Plants (Basel, Switzerland) · 2022Review
- Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis.Metabolites · 2021Review
- The sustainable cycle of a new cacao-based bioplastic: from manufacturing to exploitable biodegradation products.RSC advances · 2021Article
- Apple quality identification and classification by image processing based on convolutional neural networks.Scientific reports · 2021Article
- Applications of ambient ionization mass spectrometry in 2020: An annual review.Analytical science advances · 2021Review
- Biochemical Origin of Raman-Based Diagnostics of Huanglongbing in Grapefruit Trees.Frontiers in plant science · 2021Article
- Raman-Based Diagnostics of Biotic and Abiotic Stresses in Plants. A Review.Frontiers in plant science · 2020Review
- Rapid, Sensitive, and Versatile: A 5-Year Perspective on Applications of Ambient Ionization Mass Spectrometry in Bioanalytical Science.Mass spectrometry reviewsReview
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Authors and funding
9 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Huanglongbing (HLB) is a disease of worldwide incidence that affects orange trees, among other commercial varieties, implicating in great losses to the citrus industry. The disease is transmitted through Diaphorina citri vector, which inoculates Candidatus Liberibacter spp. in the plant sap. HLB disease lead to blotchy mottle and fruit deformation, among other characteristic symptoms, which induce fruit drop and affect negatively the juice quality. Nowadays, the disease is controlled by eradication of sick, symptomatic plants, coupled with psyllid control. Polymerase chain reaction (PCR) is the technique most used to diagnose the disease; however, this methodology involves high cost and extensive sample preparation. Mass spectrometry imaging (MSI) technique is a fast and easily handled sample analysis that, in the case of Huanglongbing allows the detection of increased concentration of metabolites associated to the disease, including quinic acid, phenylalanine, nobiletin and sucrose. The metabolites abieta-8,11,13-trien-18-oic acid, suggested by global natural product social molecular networking (GNPS) analysis, and 4-acetyl-1-methylcyclohexene showed a higher distribution in symptomatic leaves and have been directly associated to HLB disease. Desorption electrospray ionization coupled to mass spectrometry imaging (DESI-MSI) allows the rapid and efficient detection of biomarkers in sweet oranges infected with Candidatus Liberibacter asiaticus and can be developed into a real-time, fast-diagnostic technique.
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