ArticleDiabetes2020
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis.
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Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Endocannabinoids and related lipids in host metabolism-gut microbiome signalling.Nature reviews. Endocrinology · 2026Review
- The emerging role of branched-chain amino acid metabolism in obesity.International journal of obesity (2005) · 2026Review
- Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer.npj metabolic health and disease · 2025Review
- The relationship between amino acid intake patterns and both general and central obesity.BMC nutrition · 2025Article
- Essential amino acids preserve intestinal barrier integrityFrontiers in pharmacology · 2025Article
- Editorial: Nutrition as a pharmacological approach to metabolic disorders and ageing.Frontiers in pharmacology · 2025Article
- Dietary supplementation with a designer metabolic modulator improves MASLD and associated anxiety in mice.Frontiers in pharmacology · 2025Article
- What Nutraceuticals Can Do for Duchenne Muscular Dystrophy: Lessons Learned from Amino Acid Supplementation in Mouse Models.Biomedicines · 2023Review
- Comparison of Protein- or Amino Acid-Based Supplements in the Rehabilitation of Men with Severe Obesity: A Randomized Controlled Pilot Study.Journal of clinical medicine · 2023Article
- Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction.Cardiovascular research · 2023Article
- A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult.Frontiers in neuroscience · 2023Article
- Article
- The role of the gut microbiota in health and cardiovascular diseases.Molecular biomedicine · 2022Review
- Essential Amino Acids-Rich Diet Decreased Adipose Tissue Storage in Adult Mice: A Preliminary Histopathological Study.Nutrients · 2022Article
- An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition.Molecular metabolism · 2022Article
- Excess branched-chain amino acids alter myotube metabolism and substrate preference which is worsened by concurrent insulin resistance.Endocrine · 2022Article
- (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders.Lipids in health and disease · 2022Review
- Effect of Frying Process on Nutritional Property, Physicochemical Quality, andFrontiers in nutrition · 2022Article
- The Main Anthocyanin Monomer fromFoods (Basel, Switzerland) · 2021Article
- The regulation of healthspan and lifespan by dietary amino acids.Translational medicine of aging · 2021Article
Corrections and comments
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Authors and funding
32 authors at 10 institutions in 4 countries.
Chiara RuoccoCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.
Maurizio RagniCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.
Fabio RossiCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.
Pierluigi CarulloIRCCS Humanitas Clinical and Research Center, Rozzano, Italy.
Veronica GhiniInteruniversity Consortium for Magnetic Resonance, Sesto Fiorentino, Italy.
Fabiana PiscitelliInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Adele CutignanoInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Emiliano ManzoInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Rafael Maciel IorisDepartment of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Franck BontemsDepartment of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Laura TedescoCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.
Carolina M GrecoIRCCS Humanitas Clinical and Research Center, Rozzano, Italy.
Annachiara PinoDepartment of Diagnostics and Public Health, University of Verona, Verona, Italy.
Ilenia SeveriDepartment of Experimental and Clinical Medicine, Marche Polytechnic University, Center of Obesity, Ancona, Italy.
Dianxin LiuDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Ryan P CeddiaDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Luisa PonzoniCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.
Leonardo TenoriFiorGen Foundation, Sesto Fiorentino, Italy.
Lisa RizzettoDepartment of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy.
Matthias ScholzDepartment of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy.
Kieran TuohyDepartment of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy.
Francesco BifariLaboratory of Cell Metabolism and Regenerative Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Vincenzo Di MarzoCanada Excellence Research Chair Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Quebec City, Canada.
Claudio LuchinatInteruniversity Consortium for Magnetic Resonance, Sesto Fiorentino, Italy.
Michele O CarrubaCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.
Saverio CintiDepartment of Experimental and Clinical Medicine, Marche Polytechnic University, Center of Obesity, Ancona, Italy.
Ilaria DecimoDepartment of Diagnostics and Public Health, University of Verona, Verona, Italy.
Gianluigi CondorelliIRCCS Humanitas Clinical and Research Center, Rozzano, Italy.
Roberto CoppariDepartment of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Sheila CollinsDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Alessandra ValerioDepartment of Molecular and Translational Medicine, Brescia University, Brescia, Italy.
Enzo NisoliCenter for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy enzo.nisoli@unimi.it.ORCID 0000-0002-6670-1630
University of Milan · ITNational Research Council · ITFondazione Edmund Mach · ITHumanitas University · ITInteruniversity Consortium for Magnetic Resonance · ITUniversity of Geneva · CHVanderbilt University Medical Center · USMarche Polytechnic University · ITUniversity of Verona · ITUniversity of Brescia · IT
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MNIDDK NIH HHS P30 DK058404
Abstract
Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary and molecular mechanisms able to improve energy metabolism is of paramount medical importance because such mechanisms can be leveraged as a therapy for obesity and related disorders. Here, we show that a designer protein-deprived diet enriched in free essential amino acids can
Indexed as
HomeostasisAdipokinesAmino AcidsAnimal FeedAnimalsBody CompositionDietDietary ProteinsEnergy MetabolismGlucoseLongevityMiceMice, Inbred C57BLObesityAdipokinesAmino AcidsDietary ProteinsGlucose
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.