Evidence map›Paper›PMID 32778549›Full record

ArticleAntimicrobial agents and chemotherapy2020

Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing

Shampa Das, Adam Johnson, Laura McEntee, Nicola Farrington, Adam Kirby, Jennifer Unsworth, Ana Jimenez-Valverde, Ruwanthi Kolamunnage-Dona, Justine Bousquet, Laethitia Alibaud and 4 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  2. Treatment Options for Metallo-Beta-Lactamase-ProducingInternational journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Antimicrobial agents and chemotherapy · 2024
    Article
  6. Frontiers in pharmacology · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Reply to Asempa et al., "The Ongoing Challenge with NDM-HarboringAntimicrobial agents and chemotherapy · 2021
    Article
  13. The Ongoing Challenge with NDM-HarboringAntimicrobial agents and chemotherapy · 2021
    Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Shampa Das *Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.ORCID 0000-0002-2540-4816
Adam Johnson *Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Laura McEnteeAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Nicola FarringtonAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Adam KirbyAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Jennifer UnsworthAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Ana Jimenez-ValverdeAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Ruwanthi Kolamunnage-DonaDepartment of Biostatistics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Justine BousquetAntabio SAS, Labège, France.
Laethitia AlibaudAntabio SAS, Labège, France.
Carole SableAntabio SAS, Labège, France.
Magdalena ZalacainAntabio SAS, Labège, France.
Martin EverettAntabio SAS, Labège, France.ORCID 0000-0003-2002-1805
William HopeAntimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom william.hope@liverpool.ac.uk.ORCID 0000-0001-6187-878X
University of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

beta-Lactamase InhibitorsEnterobacteriaceae InfectionsAnimalsAnti-Bacterial Agentsbeta-LactamasesEnterobacteriaceaeMeropenemMiceMicrobial Sensitivity TestsMonobactamsAnti-Bacterial Agentsbeta-Lactamase Inhibitorsbeta-LactamasesMeropenemMonobactamsANT2681antimicrobial agentsantimicrobial combinationsbeta-lactamasesbeta-lactamsEnterobacteriaceaemeropenemmetalloenzymespharmacodynamicsPK/PD

Identifiers

PMID32778549
PMCPMC7577127
OpenAlexW3048552643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.