ArticleNeuron2020
Plasticity and Spontaneous Activity Pulses in Disused Human Brain Circuits.
2 registry-linked trialsOpen access · bronzeAbstract readVideo-Audio Media
In one paragraph
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 113 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Whole-Body Hyperthermia for Mood and Anxiety Disorders
Precision Neuroimaging of Parkinson's Disease
Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.
- Exploratory Study of the Brain Response in Facial Synkinesis after Bell Palsy with Systematic Review and Meta-analysis of the Literature.AJNR. American journal of neuroradiology · 2022Pooled it
- Trial
- Priming cardiovascular exercise improves complex motor skill learning by affecting the trajectory of learning-related brain plasticity.Scientific reports · 2022Trial
- Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults.Scientific reports · 2021Trial
- Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula-bed nucleus of the stria terminalis resting-state functional connectivity.Alcoholism, clinical and experimental research · 2021Trial
- Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026Article
- Excessive Censoring Degrades Individual-Specific Cortical Parcellations and Personalized TMS Targets.bioRxiv : the preprint server for biology · 2026Article
- Article
- Long-Acting Naltrexone Restores Network Connectivity in Subjects With Comorbid Cannabis and Opioid Use Disorder.Addiction biology · 2026Article
- Parallel processing chains span cytoarchitectures to organize association cortex.bioRxiv : the preprint server for biology · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Brain organization of a memory champion.bioRxiv : the preprint server for biology · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Commonality and Variability in Functional Networks in Children Under 5 Years Old.bioRxiv : the preprint server for biology · 2026Article
- Precision estimates of longitudinal brain aging capture unexpected individual differences in one year.Nature communications · 2026Article
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Patterns of brain-wide associations reflect socioeconomics.bioRxiv : the preprint server for biology · 2025Article
- Long-acting naltrexone restores network connectivity in subjects with co-morbid cannabis and opioid use disorder.bioRxiv : the preprint server for biology · 2025Article
- Spatiotemporal Patterns in Cortical Development: Age, Puberty, and Individual Variability from 9 to 13 Years of Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
24 authors at 4 institutions in 1 country.
Dillan J NewboldDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: newbold@wustl.edu.
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Catherine R HoytProgram in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jacqueline M HamptonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
David F MontezDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ryan V RautDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mario OrtegaDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Anish MitraDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Stanford University, Stanford, CA 94305, USA.
Ashley N NielsenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL 60611, USA.
Derek B MillerDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Babatunde AdeyemoDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Annie L NguyenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kristen M ScheidterDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Aaron B TanenbaumDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew N VanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA.
Scott MarekDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bradley L SchlaggarDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Kennedy Krieger Institute, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Alexandre R CarterDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA.
Deanna J GreeneDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Evan M GordonVISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75080, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76706, USA.
Marcus E RaichleDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Steven E PetersenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA.
Abraham Z SnyderDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: dosenbachn@wustl.edu.
Washington University in St. Louis · USKennedy Krieger Institute · USNorthwestern University · USVA Heart of Texas Health Care Network · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MIMAGING COREP01NS080675 · NINDS · WASHINGTON UNIVERSITY · PI RAICHLE, MARCUS E · 2013 to 2017
$6.2MDevelopmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8MNINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G, MARCUS, DANIEL SCOTT · 2016 to 2019
$2.4MWashington University Psychiatry Residency Research Education ProgramR25MH112473 · NIMH · WASHINGTON UNIVERSITY · PI NURI B FARBER, Timothy Eric Spiegel · 2018 to 2026
$1.6MPEDIATRIC BRAIN INJURY RECOVERY VIA USE-DRIVEN FUNCTIONAL NETWORK REORGANIZATIONK23NS088590 · NINDS · WASHINGTON UNIVERSITY · PI DOSENBACH, NICO · 2015 to 2019
$886kPREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723kNeurodevelopmental profiles related to transdiagnostic and disorder-specific symptoms of anxiety and depressionK99MH121518 · NIMH · WASHINGTON UNIVERSITY · PI MAREK, SCOTT · 2020 to 2021
$228kDynamics in resting and task-based functional connectivityF30MH100872 · NIMH · WASHINGTON UNIVERSITY · PI LAUMANN, TIMOTHY OTTO · 2013 to 2016
$145kHuman network plasticity caused by disuseF31NS110332 · NINDS · WASHINGTON UNIVERSITY · PI NEWBOLD, DILLAN JACOB · 2019 to 2021
$94kNeuroimaging-based identification of Traumatic Brain Injury subtypesIK2CX001680 · VA · OLIN TEAGUE VETERANS CENTER · PI GORDON, EVAN M. · 2019 to 2021
–CSRD VA IK2 CX001680NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIMH NIH HHS F30 MH100872NIMH NIH HHS K01 MH104592NIMH NIH HHS K99 MH121518NIMH NIH HHS R25 MH112473NIMH NIH HHS T32 MH100019NINDS NIH HHS F31 NS110332NINDS NIH HHS K23 NS088590NINDS NIH HHS P01 NS080675NINDS NIH HHS P30 NS098577
Abstract
To induce brain plasticity in humans, we casted the dominant upper extremity for 2 weeks and tracked changes in functional connectivity using daily 30-min scans of resting-state functional MRI (rs-fMRI). Casting caused cortical and cerebellar regions controlling the disused extremity to functionally disconnect from the rest of the somatomotor system, while internal connectivity within the disused sub-circuit was maintained. Functional disconnection was evident within 48 h, progressed throughout the cast period, and reversed after cast removal. During the cast period, large, spontaneous pulses of activity propagated through the disused somatomotor sub-circuit. The adult brain seems to rely on regular use to maintain its functional architecture. Disuse-driven spontaneous activity pulses may help preserve functionally disconnected sub-circuits.
Indexed as
Restraint, PhysicalActivities of Daily LivingCasts, SurgicalFemaleFunctional LateralityFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMotor CortexMotor SkillsMuscle StrengthNeural PathwaysNeuronal PlasticityUpper ExtremityALFFamplitude of low-frequency fluctuationscerebellumdisusefMRIfunctional connectivityplasticityprimary motor cortexresting statespontaneous activitysupplementary motor area
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06144294ClinicalTrials.gov
NCT07024875ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.