Evidence map›Paper›PMID 32778076›Full record

ArticleBMC urology2020

Elevated non-high-density lipoprotein cholesterol corresponds to a high risk of nephrolithiasis in children.

Meiyuan Chen, Jing Xiao, Yuan Du, Miaomiao Wang, Jimeng Ruan, Ye Tian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meiyuan ChenDepartment of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China. Meiyuan.chen@gmail.com.ORCID http://orcid.org/0000-0002-3182-2053
Jing XiaoDepartment of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China.
Yuan DuDepartment of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China.
Miaomiao WangDepartment of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China.
Jimeng RuanDepartment of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China.
Ye TianDepartment of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China. Tianye166@126.com.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia contributes to the development of nephrolithiasis in adults; however its relationship to urolithiasis in children remains debatable, and will be clarified in the present work.

methodsA case-control study was performed involving 58 pediatric patients diagnosed with upper urinary tract stones as well as 351 controls. Age, gender, body mass index (BMI), serum calcium, serum uric acid, blood glucose, blood lipids, and compositions of stones were compared.

resultsAccording to the univariate analysis, uric acid was higher (P < 0.01) but serum calcium lower in the stone group than the control (P < 0.05). As for the blood lipids, non-high-density lipoprotein cholesterol (non-HDL-c) was significantly higher in the stone group as compared to the control (P < 0.01), while total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol did not show statistical difference between the two groups. In the multivariate analysis, only non-HDL-c and serum uric acid were increased in the stone group (P = 0.003 and P = 0.008). In the stone compositions' analysis, serum uric acid and non-HDL-c were associated with percentage of uric acid and pure calcium oxalate stones, respectively.

conclusionNon-high-density lipoprotein cholesterol may act as a lipid risk factor for urolithiasis in children.

Indexed as

Case-Control StudiesChildChild, PreschoolCholesterolDyslipidemiasFemaleHumansLipoproteinsMaleRisk AssessmentUrinary CalculiCholesterollipoprotein cholesterolLipoproteinsChildDyslipidemiasNon-HDL cholesterolUrolithiasis

Identifiers

PMID32778076
PMCPMC7419197
OpenAlexW3048823512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.