Evidence map›Paper›PMID 32778058›Full record

ArticleBMC infectious diseases2020

The reduction in CD8

Ruyu Liu, Yanhui Chen, Jiang Guo, Minghui Li, Yao Lu, Lu Zhang, Ge Shen, Shuling Wu, Min Chang, Leiping Hu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ruyu LiuDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China. liuruyu28@163.com.ORCID http://orcid.org/0000-0001-7561-9439
Yanhui ChenInstitute of Infectious Diseases, Beijing Ditan Hospital, Beijing Key Laboratory of Emerging Infectious Diseases, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Jiang GuoTumor Interventional Department, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Minghui LiDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Yao LuDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Lu ZhangDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Ge ShenDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Shuling WuDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Min ChangDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Leiping HuDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Hongxiao HaoDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.
Henghui ZhangInstitute of Infectious Diseases, Beijing Ditan Hospital, Beijing Key Laboratory of Emerging Infectious Diseases, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China. zhhbao@ccmu.edu.cn.
Yao XieDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China. xieyao00120184@sina.com.
Capital Medical University · CN

Funding

Beijing Hospitals Authority Incubating Program PX2018060Beijing Hospitals Authority Youth Programme QML20181803National Key Sci-Tech Special Project of China 2018ZX10302207
6 · The paper itself

Abstract

backgroundAntiviral therapy is recommended for patients with immune-active chronic hepatitis B (CHB) to decrease the risk of liver-related complications. However, the outcomes of the pegylated IFN-α (PEG-IFN-α) therapy vary among CHB patients. We aimed to identify factors that can influence the outcomes in CHB patients who received antiviral PEG-IFN-α monotherapy.

methodsThirty-two CHB patients who received PEG-IFN-α monotherapy were enrolled in this study. All of the patients underwent two liver biopsies at baseline and 6 months after the initiation of the therapy. CD8

resultsThe overall median frequency of CD8

conclusionsThe changes in the levels of CD8

Indexed as

AdultAntigens, CDAntigens, Differentiation, MyelomonocyticAntiviral AgentsCD68 MoleculeCD8-Positive T-LymphocytesFemaleHepatitis B, ChronicHepatitis B e AntigensHumansInterferon-alphaLeukocytes, MononuclearLiverMalePolyethylene GlycolsProgrammed Cell Death 1 ReceptorAntigens, CDAntigens, Differentiation, MyelomonocyticAntiviral AgentsCD68 antigen, humanCD68 MoleculeHepatitis B e AntigensInterferon-alphapeginterferon alfa-2aPolyethylene GlycolsProgrammed Cell Death 1 ReceptorRecombinant ProteinsCD4+ T cellsCD68+ mononuclear cellsCD8+ T cellsChronic hepatitis BPD-1Pegylated IFN-α

Identifiers

PMID32778058
PMCPMC7418392
OpenAlexW3047813853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.