ArticleBMC anesthesiology2020
Deep sedation using propofol target-controlled infusion for gastrointestinal endoscopic procedures: a retrospective cohort study.
Article in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- High-flow nasal cannula oxygenation in sedated endoscopy for high-risk obstructive sleep apnea patients: study protocol for a multicentre randomised controlled trial.Annals of medicine · 2026Trial
- Oxygen reserve index monitoring reduced the incidence of low pulse oxygen saturation during deep sedation for hysteroscopy: a prospective randomized controlled trial.Frontiers in medicine · 2026Trial
- Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy: A randomized clinical trial.World journal of gastrointestinal endoscopy · 2025Trial
- Effect of Intravenous Lidocaine (1.0 mg/Kg) on Propofol ED50 and ED95 for Successful Double-Lumen Laryngeal Mask Airway Placement in Hysteroscopy Patients: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method.BMC anesthesiology · 2024Trial
- Remimazolam versus propofol in combination with esketamine for surgical abortion: A double-blind randomized controlled trial.Clinical and translational science · 2023Trial
- Comparison of three sedation models for same-day painless bidirectional endoscopy: A multicenter randomized controlled trial.Journal of gastroenterology and hepatology · 2022Trial
- ED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method.Drug design, development and therapy · 2022Trial
- Discretionary Versus Routine Intravenous Fluids for Ambulatory Gastrointestinal Endoscopies: A Cohort Study Following Hurricane Helene.Digestive diseases and sciences · 2026Article
- Review
- Determination of the 95% Effective Dose of Remifentanil for Moderate Sedation During Gastroscopy in Obese Patients.Current medicinal chemistry · 2026Article
- Safety and efficacy of cipepofol for painless digestive endoscopy in older patients: a randomized, double-blind, non-inferiority trial.BMC geriatrics · 2025Article
- Clinical efficacy of COMBO endoscopy of oropharyngeal airways in elderly patients undergoing painless gastroenteroscopy under anaesthesia: a randomized controlled trial protocol.BMC anesthesiology · 2025Article
- Risk factors for adverse reactions to nurse-administered propofol during outpatient endoscopy: a cross-sectional study.BMC anesthesiology · 2025Article
- Optimal sedation/anesthesia practices for painless gastroscopy in older adults: a randomized trial.Frontiers in medicine · 2025Article
- Efficacy and Safety of Deep Sedation and Anaesthesia for Complex Endoscopic Procedures-A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- A single nucleotide polymorphism-based formula to predict the risk of propofol TCI concentration being over 4 µg mLThe pharmacogenomics journal · 2022Article
- Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients.Frontiers in medicine · 2022Article
- A Bibliometric Analysis of Endoscopic Sedation Research: 2001-2020.Frontiers in medicine · 2021Article
- Clinical observation of the combined use of propofol and etomidate in painless gastroscopy.Medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPropofol sedation is effective for gastrointestinal endoscopic procedures, but its narrow therapeutic window highlights the importance of identifying an optimal administration technique regarding effectiveness and safety. This study aimed to determine the incidence of significant adverse events in adult patients scheduled for gastrointestinal endoscopy under anaesthetist-performed sedation using propofol target-controlled infusion and determine the existence of associations between these events and potentially related variables.
methodsThis single-centre, retrospective cohort study took place in a tertiary referral university hospital. Medical records of 823 patients (age > 18 years, American Society of Anesthesiologists physical status classification scores I-III) who had undergone elective gastrointestinal endoscopy under propofol target-controlled infusion sedation during September 2018 were reviewed. Outcomes included hypoxia, hypotension, and bradycardia events, requirement of vasoactive drugs, unplanned tracheal intubation or supraglottic device insertion, and need for advanced cardiac life support.
resultsThe most frequently encountered adverse event was oxygen desaturation < 95% with an incidence of 22.35%. Vasoactive drug administration, hypotension, and oxygen desaturation < 90% followed, with incidences of 19.2, 12.64, and 9.92%, respectively. Only 0.5% of patients required advanced airway management. Multivariate analysis revealed an association between hypotension events, colonoscopic procedures, and propofol doses (odds ratio: 3.08, 95% confidence interval: 1.43 to 6.61; P = 0.004 and odds ratio: 1.14, 95% confidence interval: 1.00 to 1.29; P = 0.046). A strong dose-effect relationship was found between hypoxia and obesity; patients with body mass index ≥40 were nine times (odds ratio: 10.22, 95% confidence interval: 2.83 to 36.99) more likely to experience oxygen desaturation < 90% events.
conclusionsPropofol sedation using target-controlled infusion appears to be a safe and effective anaesthetic technique for gastrointestinal endoscopic procedures with acceptable rates of adverse events and could be more widely adopted in clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.