ArticleDigestive diseases (Basel, Switzerland)2021
Mild versus Severe Liver Injury in SARS-CoV-2 Infection.
Article in Digestive diseases (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Is liver involvement overestimated in COVID-19 patients? A meta-analysis.International journal of medical sciences · 2021Pooled it
- Involvement of the digestive system in covid-19. A review.Gastroenterologia y hepatologia · 2020Pooled it
- COVID-19 and chronic liver disease: results from the 1219 patients French registry.Scientific reports · 2025Article
- Impact of Elevated Liver Enzymes on the Severity of Clinical Course of COVID-19: A Retrospective Study From Saudi Arabia.International journal of hepatology · 2025Article
- Liver dysfunction on admission worsens clinical manifestations and outcomes of coronavirus disease 2019.Chinese medical journal pulmonary and critical care medicine · 2023Article
- Association between acute liver injury & severity and mortality of COVID-19 patients: A systematic review and meta-analysis.Heliyon · 2023Article
- Liver injury in hospitalized patients with COVID-19: An International observational cohort study.PloS one · 2023Observational
- Article
- Molecular, Viral and Clinical Features of Alcohol- and Non-Alcohol-Induced Liver Injury.Current issues in molecular biology · 2022Review
- Severe Acute Respiratory Syndrome Coronavirus-2 Infection in Children With Liver Transplant and Native Liver Disease: An International Observational Registry Study.Journal of pediatric gastroenterology and nutrition · 2021Observational
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormal liver function has been reported in patients with COVID-19 infection. The aim of our study was to report on the prevalence of liver injury in our cohort, to evaluate the association of mild versus severe liver injury with mortality in COVID-19 patients and to scrutinize the temporal pattern of viral detection and liver injury.
methodsWe present data from a German cohort of 147 SARS-CoV-2 infected patients. The patients were divided into 3 groups according to their liver status during treatment. The first group included patients without elevated alanine aminotransferase or bilirubin, the third group patients meeting the biochemical criteria of acute liver failure (ALF), and the second group all other patients.
resultsLiver injury was detected in 75 (50.7%) and 93 (63%) patients by admission and during treatment, respectively. ALF was associated with the male sex, younger age, and higher BMI. Mortality was associated with the presence of ALF (OR = 9.423, 95% CI: 2.410-36.858) in contrast to milder liver injury (OR 1.101, 95% CI: 0.435-2.791). In 30% of patients with mild liver injury and in 50% of ALF patients, peak liver injury was observed at a time point when the virus was no longer detectable in the respiratory tract.
conclusionMild liver injury was not associated with worse outcome in our cohort, and the pattern of liver injury did not fit well to the theory of SARS-CoV-2 directly causing liver impairment. Instead, severe liver injury in our cohort was associated multiple-organ failure and acute vascular events.
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