ReviewiScience2020
Holo-Omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research.
Review in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 166 citations in OpenAlex.
- The microbial metabolome: remodeling the therapeutic landscape in hematologic malignancies.NPJ biofilms and microbiomes · 2026Review
- Challenges and Opportunities in Multi-Omics Data Acquisition and Analysis: Toward Integrative Solutions.Biomolecules · 2026Review
- The hologenome concept and its implications for animal breeding in the multi-omics Era.Genetics and molecular biology · 2026Article
- Symbiotic interactions of plant microbiota in alleviating stress: a review.Frontiers in plant science · 2026Review
- OmniCorr: an R-package for visualizing putative host-microbiome interactions using multi-omics data.Bioinformatics advances · 2026Article
- Unravelling the impacts of captivity on saltwater crocodile (Crocodylus porosus) cloacal bacterial communities and physiology.FEMS microbiology ecology · 2025Article
- Robust, Open-Source and Automation-Friendly DNA Extraction Protocol for Hologenomic Research.Molecular ecology resources · 2025Article
- HoloFoodR: a statistical programming framework for holo-omics data integration workflows.Bioinformatics (Oxford, England) · 2025Article
- Amoebic Gill Disease (AGD) in Atlantic Salmon Investigated Through a Holo-Omic Lens.Ecology and evolution · 2025Article
- A genomic view of the bacterial family Endozoicomonadaceae in marine symbioses.Communications biology · 2025Review
- The crosstalk between host and rumen microbiome in cattle: insights from multi-omics approaches and genome-wide association studies.World journal of microbiology & biotechnology · 2025Review
- Interplay between antipredator behavior, parasitism, and gut microbiome in wild stickleback populations.NPJ biofilms and microbiomes · 2025Article
- Modulation of Gut Microbial Composition byNutrients · 2025Article
- Advancing Gut Microbiome Research: The Shift from Metagenomics to Multi-Omics and Future Perspectives.Journal of microbiology and biotechnology · 2025Review
- Bioinformatic approaches to blood and tissue microbiome analyses: challenges and perspectives.Briefings in bioinformatics · 2025Review
- Short communication: imputation accuracy of host genomic data from metagenomic sequence information.Journal of animal science · 2025Article
- Growth promotion and stress tolerance of soybean plants driven by seed treatment with synthetic bacterial community of soybean-associated beneficial bacteria.Frontiers in plant science · 2025Article
- Microbial Dynamics in COVID-19: Unraveling the Impact of Human Microbiome on Disease Susceptibility and Therapeutic Strategies.Current microbiology · 2024Review
- Deciphering Molecular Mechanisms and Diversity of Plant Holobiont Bacteria: Microhabitats, Community Ecology, and Nutrient Acquisition.International journal of molecular sciences · 2024Review
- A practical introduction to holo-omics.Cell reports methods · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by the bidirectional interactions between the host organisms and their associated microbiota. Current technology can reveal many such interactions by combining multi-omic data from both hosts and microbes. However, exploring the full extent of these interactions requires careful consideration of study design for the efficient generation and optimal integration of data derived from (meta)genomics, (meta)transcriptomics, (meta)proteomics, and (meta)metabolomics. In this perspective, we introduce the holo-omic approach that incorporates multi-omic data from both host and microbiota domains to untangle the interplay between the two. We revisit the recent literature on biomolecular host-microbe interactions and discuss the implementation and current limitations of the holo-omic approach. We anticipate that the application of this approach can contribute to opening new research avenues and discoveries in biomedicine, biotechnology, agricultural and aquacultural sciences, nature conservation, as well as basic ecological and evolutionary research.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.