Evidence map›Paper›PMID 32777374›Full record

ArticleAmerican journal of ophthalmology2021

An Evaluation of a New 24-2 Metric for Detecting Early Central Glaucomatous Damage.

Donald C Hood, Abinaya A Thenappan, Emmanouil Tsamis, Jeffrey M Liebmann, C Gustavo De Moraes

Abstract read
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Visualising structural and functional characteristics distinguishing between newly diagnosed high-tension and low-tension glaucoma patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donald C HoodDepartment of Psychology, Columbia University, New York, New York, USA; Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Columbia University Medical Center, New York, New York, USA. Electronic address: dch3@columbia.edu.
Abinaya A ThenappanColumbia Vagelos College of Physicians and Surgeons, New York, New York, USA.
Emmanouil TsamisDepartment of Psychology, Columbia University, New York, New York, USA.
Jeffrey M LiebmannBernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Columbia University Medical Center, New York, New York, USA.
C Gustavo De MoraesBernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Columbia University Medical Center, New York, New York, USA.

Funding

Tests of Models of Retinal/Optic Nerve Diseases&AdaptionR01EY002115 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HOOD, DONALD C. · 1985 to 2018
$7.4M
Structural and Functional Progression of Glaucomatous Damage to the MaculaR01EY025253 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE MORAES, CARLOS GUSTAVO · 2015 to 2017
$1.2M
NEI NIH HHS R01 EY002115NEI NIH HHS R01 EY025253
6 · The paper itself

Abstract

purposeWe sought to test the hypothesis that a recently proposed pattern standard deviation (PSD) metric, based upon the 24-2 visual field (VF) test, as well as the PSD of the 10-2 VF, will miss central glaucomatous damage confirmed with an objective structure-function method.

designCross-sectional study.

methodsA glaucoma (G) group (70 eyes/patients) diagnosed with glaucoma and a 24-2 mean deviation better than -6 dB and a healthy (H) group (45 eyes/patients) had 24-2 and 10-2 VFs and optical coherence tomography (OCT) scans twice within 4 weeks. The PSD(C24-2), based upon the central 12 points of the 24-2, was compared with the PSD(10-2). To evaluate central damage (CD) in G eyes with normal PSD(C24-2) values, a post hoc analysis was combined with a CD reference standard (CD-RS), which was based upon an objective, topographic comparison between abnormal points on the 10-2 VF and OCT probability maps.

resultsThe 115 PSD(C24-2) and PSD(10-2) values were significantly correlated (Spearman correclation coefficient: rho = 0.55; P < .001) and the number of G eyes (19) identified as abnormal by the PSD(C24-2) was not significantly different from the number (22) identified by the PSD(10-2) (P = .15). However, based upon the CD-RS, 44 of 70 G eyes were classified as abnormal. The PSD(C24-2) missed 27 (61%) of these 44 eyes, and the PSD(10-2) missed 23 (52%) of these eyes. Post hoc analysis revealed clear CD in most of these eyes.

conclusionNeither the PSD(C24-2) nor the PSD(10-2) metric is good measure of early CD. Instead we recommend a topographic approach based upon OCT probability maps and a 10-2 VF.

Indexed as

Visual Field TestsAdultAgedCross-Sectional StudiesEarly DiagnosisFemaleGlaucoma, Open-AngleHumansMaleMiddle AgedNerve FibersOptic Nerve DiseasesProbabilityReference StandardsRetinal Ganglion CellsSensitivity and Specificity

Identifiers

PMID32777374
PMCPMC7871214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.