Evidence map›Paper›PMID 32777343›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2020

Periostin and matrix stiffness combine to regulate myofibroblast differentiation and fibronectin synthesis during palatal healing.

Georgia Nikoloudaki, Paige Snider, Olga Simmons, Simon J Conway, Douglas W Hamilton

Open access · greenAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

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  11. Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
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  19. Editorial: In celebration of women in cell adhesion and migration.Frontiers in cell and developmental biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Georgia NikoloudakiDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada. Electronic address: gnikolou@uwo.ca.
Paige SniderHerman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut, Indianapolis, IN, United States.
Olga SimmonsHerman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut, Indianapolis, IN, United States.
Simon J ConwayHerman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut, Indianapolis, IN, United States.
Douglas W HamiltonDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada; Division of Oral Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada. Electronic address: dhamil2@uwo.ca.
Indiana University School of MedicineWestern University · CA

Funding

Mechanisms of cardiac and pulmonary fibrosis in relation to TGF-beta signaling and miR-145 functionR01HL135657 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CONWAY, SIMON JAMES, LILLY, BRENDA J · 2017 to 2020
$1.7M
CIHRNHLBI NIH HHS R01 HL135657
6 · The paper itself

Abstract

Although the matricellular protein periostin is prominently upregulated in skin and gingival healing, it plays contrasting roles in myofibroblast differentiation and matrix synthesis respectively. Palatal healing is associated with scarring that can alter or restrict maxilla growth, but the expression pattern and contribution of periostin in palatal healing is unknown. Using periostin-knockout (Postn

Indexed as

ActinsAnimalsCell Adhesion MoleculesCell DifferentiationDisease Models, AnimalFibroblastsFibronectinsHumansIntegrin beta1MaxillaMiceMice, KnockoutMyofibroblastsPalate, HardrhoA GTP-Binding ProteinSignal TransductionActa2 protein, mouseActinsalpha-smooth muscle actin, mouseCell Adhesion MoleculesFibronectinsIntegrin beta1Itgb1 protein, mousePostn protein, mouserhoA GTP-Binding ProteinRhoA protein, mouseAdhesionFibronectinMatrix complianceMyofibroblastPalatal healingPeriostinRhoAβ1-integrin

Identifiers

PMID32777343
PMCPMC8922408
OpenAlexW3048125906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.