ReviewPhysiology & behavior2020
Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.
Review in Physiology & behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Article
- Sign- vs. goal-tracking is associated with greater adiposity and altered functional connectivity in response to a naturalistic food paradigm.Physiology & behavior · 2025Article
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment.Neuropharmacology · 2024Article
- The Psychological Impact of the Widespread Availability of Palatable Foods Predicts Uncontrolled and Emotional Eating in Adults.Foods (Basel, Switzerland) · 2023Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium.The American journal of clinical nutrition · 2023Article
- Actions and Consequences of Insulin in the Striatum.Biomolecules · 2023Review
- Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.Journal of neurochemistry · 2023Article
- Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity-prone female rats.Obesity (Silver Spring, Md.) · 2023Article
- Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone.International journal of molecular sciences · 2023Article
- Diet and obesity effects on cue-driven food-seeking: insights from studies of Pavlovian-instrumental transfer in rodents and humans.Frontiers in behavioral neuroscience · 2023Review
- Acute high-intensity interval exercise attenuates incubation of craving for foods high in fat.Obesity (Silver Spring, Md.) · 2022Article
- Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting.International journal of obesity (2005) · 2022Review
- The Association Between Food Addiction and Weight Status in School-Age Children and Adolescents.Frontiers in psychiatry · 2022Article
- The role of reinforcement learning and value-based decision-making frameworks in understanding food choice and eating behaviors.Frontiers in nutrition · 2022Review
- Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Crème de la Créature: Dietary Influences on Behavior in Animal Models.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Obesity is one of the leading causes of preventable illness in the US. The ability to seek out and find food relies in large part on activation on mesocorticolimbic regions including the nucleus accumbens (NAc). There is an emerging literature suggesting that enhanced NAc responsivity to food cues may promote weight gain and hamper weight loss, particularly in obesity-susceptible individuals. This article summarizes recent work examining basal and diet-induced alterations in NAc function and cue-triggered food-seeking in obesity-prone and -resistant rodent models, with an emphasis on differences in glutamatergic plasticity and Pavlovian incentive motivation. Overall, results suggest that enhanced neural and behavioral responsivity to food cues found in humans may be due in part to phenotypic differences between those that are more and less vulnerable to diet-induced weight gain. Furthermore, consumption of sugary, fatty foods results in enhanced NAc function that may help explain the drivers of initial weight gain and the difficulty some people have maintaining long-term weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.