Evidence map›Paper›PMID 32777267›Full record

ArticleOsteoarthritis and cartilage2020

Hip symptoms are associated with premature mortality: the Johnston County Osteoarthritis Project.

R J Cleveland, C Alvarez, A E Nelson, T A Schwartz, J B Renner, J M Jordan, L F Callahan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Epidemiology of Hip Osteoarthritis: The Johnston County Osteoarthritis Project.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

R J ClevelandThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: becki@unc.edu.
C AlvarezThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: alvarec@live.unc.edu.
A E NelsonThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: amanda_nelson@med.unc.edu.
T A SchwartzThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA; School of Nursing, University of North Carolina, Chapel Hill, NC, USA. Electronic address: tschwart@email.unc.edu.
J B RennerDepartment of Radiology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jordan_renner@med.unc.edu.
J M JordanThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: joanne_jordan@med.unc.edu.
L F CallahanThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA; Departments of Orthopaedics and Social Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: leigh_callahan@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
NIAMS Multidisciplinary Clinical Research CenterP60AR064166 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHWARTZ, TODD A · 2013 to 2017
$5.8M
The Johnston County OA Project: Arthritis and DisabilityU01DP003206 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JORDAN, JOANNE M. · 2011 to 2015
$3.2M
Mortality in a community sample of adults with arthritisR01AR065937 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CALLAHAN, LEIGH FLEMING, JORDAN, JOANNE M. · 2013 to 2016
$1.1M
ACL HHS U01DP003206NCCDPHP CDC HHS U01 DP003206NIAMS NIH HHS P30 AR072580NIAMS NIH HHS P60 AR064166NIAMS NIH HHS R01 AR065937
6 · The paper itself

Abstract

objectiveTo investigate the impact of hip osteoarthritis (OA) and/or hip symptoms on excess mortality.

designWe analyzed data from 3,919 individuals in a community-based prospective cohort of African Americans and Caucasians age ≥45 years. Women ≥50 years of age and all men underwent supine anteroposterior pelvic radiography at baseline, with the participant's feet in 15 degrees of internal rotation. Hip radiographic (rOA) was defined as a Kellgren-Lawrence grade of ≥2 in at least one hip. Participants completed questionnaires at baseline to determine presence of hip symptoms and covariate status. Participants with symptomatic hip rOA (SxOA) are a subset of individuals with hip rOA and symptoms in the same hip. Multiple imputation was used to impute missing values of covariates. Mortality was determined through 2015 and follow-up time was calculated from baseline assessment until death or censoring which took place when a participant was lost to follow-up or reached the end of study period. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). We carried out additional analyses stratified by sex, race, age and obesity.

resultsMean follow-up time was 14.2 years during which 1762 deaths occurred. There were 29.9% participants in our population with hip rOA at baseline. Compared to those with neither hip rOA nor hip symptoms, we observed an increased risk of all-cause mortality in participants with hip symptoms alone (HR = 1.28, 95% CI = 1.13-1.46), but no association for hip rOA either with or without symptoms. In stratified analyses we observed increased associations for hip symptoms alone and hip sxOA in those <65 years (43% and 39% increase, respectively) and in Caucasians (34% and 21% increase, respectively).

conclusionsIndividuals who had hip symptoms without hip rOA had an increased risk of mortality. These effects were particularly strong for those who were <65 years of age and Caucasians. Effective interventions to identify those with hip pain in order to lessen it could reduce premature mortality.

Indexed as

Mortality, PrematureAgedAged, 80 and overArthralgiaCohort StudiesFemaleHumansKaplan-Meier EstimateMaleMiddle AgedOsteoarthritis, HipProportional Hazards ModelsProspective StudiesSurveys and QuestionnairesEpidemiologyHip osteoarthritisJoint painMortality

Identifiers

PMID32777267
PMCPMC7530042
OpenAlexW3047961484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.