ArticleJournal of clinical periodontology2020
Salivary proteotypes of gingivitis tolerance and resilience.
Article in Journal of clinical periodontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Gingivitis Pathogenesis Involves Upregulation of Glycolysis and Citric Acid Cycle Activity Mediated by Bacterial Virulence Factors.International journal of molecular sciences · 2026Article
- Longitudinal biomarker profiles during experimental gingivitis: a predictor of susceptibility.Clinical oral investigations · 2026Article
- Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding.Oral diseases · 2026Observational
- Associations between self-reported oral health and incident stroke: a prospective analysis of the UK Biobank.BMC public health · 2026Article
- Saliva Versus All-Site Microbiome and Proteome Mapping in Periodontitis.Journal of clinical periodontology · 2025Article
- Probing the salivary proteome for prognostic biomarkers in response to non-surgical periodontal therapy.Journal of clinical periodontology · 2025Article
- Activation of cellular responses by cyclic dinucleotides andJournal of oral microbiology · 2025Article
- Bridging the gap between omics research and dental practice.BDJ open · 2024Review
- Periodontal health and pregnancy outcomes: Time to deliver.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Precision periodontal care: from omics discoveries to chairside diagnostics.Clinical oral investigations · 2023Review
- Salivary secretory leukocyte protease inhibitor levels in patients with stage 3 grade C periodontitis: a comparative cross-sectional study.Scientific reports · 2022Article
- Implementing of aMMP-8 point-of-care test with a modified new disease classification in Finnish adolescent cohorts.Clinical and experimental dental research · 2022Article
- Influence of the Gingival Condition on the Performance of Different Gingival Displacement Methods-A Randomized Clinical Study.Journal of clinical medicine · 2021Article
- Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring.Journal of personalized medicine · 2021Article
- Validation and verification of predictive salivary biomarkers for oral health.Scientific reports · 2021Article
- Gingival Crevicular Fluid Cytokines in Moderate and Deep Sites of Stage III Periodontitis Patients in Different Rates of Clinical Progression.Biomedicines · 2020Article
- Salivary proteotypes of gingivitis tolerance and resilience.Journal of clinical periodontology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to characterize the salivary proteome during the induction and resolution of gingival inflammation in the course of human experimental gingivitis (EG), and to cluster the proteomic profiles based on the clinically defined "slow" and "fast" response patterns. MATERIALS AND
methodsA total of 50 unstimulated whole saliva were obtained from the EG model which was induced over 21 days (days 0, 7, 14 and 21), followed by a two-week resolution phase (day 35). Label-free quantitative proteomics using liquid chromatography-tandem mass spectrometry was applied. Regulated proteins were subject to Gene Ontology enrichment analysis.
resultsA total of 804 human proteins were quantified by ≥ 2 peptides. Principal component analysis depicted significant differences between "fast" and "slow" responders. Despite gingival and plaque scores being similar at baseline among the two groups, "fast" responders presented with 48 proteins that were at > 4-fold higher levels than "slow" responders. These up-regulated proteins showed enrichment in "antigen presentation" and "proteolysis."
conclusionsTogether, these findings highlight the utility of integrative systems-level quantitative proteomic approaches to unravel the molecular basis of "salivary proteotypes" associated with gingivitis dubbed as "fast" and "slow" responders. Hence, these differential responses may help prognosticate individual susceptibility to gingival inflammation.
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