ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Investigating the Meat Pathway as a Source of Human Nontyphoidal Salmonella Bloodstream Infections and Diarrhea in East Africa.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Using metagenomics and whole-genome sequencing to characterize enteric pathogens across various sources in Africa.Nature communications · 2025Article
- Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi.Nature communications · 2025Article
- Phenotypic resistance and virulence gene profiles of non-typhoidalVeterinary world · 2025Article
- Article
- Shedding of nontyphoidalJournal of clinical microbiology · 2024Article
- Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa.Emerging infectious diseases · 2024Article
- Draft genome sequences of two β-glucuronidase positive strains ofMicrobiology resource announcements · 2024Article
- Genotyping virulence and resistance profiles in salmonella isolated from diarrheic children in Nairobi city, Kenya.Gastroenterology and hepatology from bed to bench · 2024Article
- Non-typhoidalFrontiers in veterinary science · 2024Article
- Non-typhoidal salmonella contamination along the pork value chain in a rural East African setting: a cross-sectional study.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- NontyphoidalOpen forum infectious diseases · 2023Article
- What is the Source of Infections Causing Invasive NontyphoidalOpen forum infectious diseases · 2023Review
- Invasive non-typhoidalFrontiers in microbiology · 2023Article
- Intestinal carriage of invasive non-typhoidalFrontiers in microbiology · 2023Article
- The Challenge Non-TyphoidalWellcome open research · 2023Article
- High diversity ofFrontiers in microbiology · 2023Article
- Case-control investigation of invasive Salmonella disease in Malawi reveals no evidence of environmental or animal transmission of invasive strains, and supports human to human transmission.PLoS neglected tropical diseases · 2022Article
- Urban rats as carriers of invasive Salmonella Typhimurium sequence type 313, Kisangani, Democratic Republic of Congo.PLoS neglected tropical diseases · 2022Article
- The costs and benefits of primary prevention of zoonotic pandemics.Science advances · 2022Article
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Authors and funding
19 authors at 9 institutions in 6 countries.
Funding
Abstract
backgroundSalmonella Enteritidis and Salmonella Typhimurium are major causes of bloodstream infection and diarrheal disease in East Africa. Sources of human infection, including the role of the meat pathway, are poorly understood.
methodsWe collected cattle, goat, and poultry meat pathway samples from December 2015 through August 2017 in Tanzania and isolated Salmonella using standard methods. Meat pathway isolates were compared with nontyphoidal serovars of Salmonella enterica (NTS) isolated from persons with bloodstream infections and diarrheal disease from 2007 through 2017 from Kenya by core genome multi-locus sequence typing (cgMLST). Isolates were characterized for antimicrobial resistance, virulence genes, and diversity.
resultsWe isolated NTS from 164 meat pathway samples. Of 172 human NTS isolates, 90 (52.3%) from stool and 82 (47.7%) from blood, 53 (30.8%) were Salmonella Enteritidis sequence type (ST) 11 and 62 (36.0%) were Salmonella Typhimurium ST313. We identified cgMLST clusters within Salmonella Enteritidis ST11, Salmonella Heidelberg ST15, Salmonella Typhimurium ST19, and Salmonella II 42:r:- ST1208 that included both human and meat pathway isolates. Salmonella Typhimurium ST313 was isolated exclusively from human samples. Human and poultry isolates bore more antimicrobial resistance and virulence genes and were less diverse than isolates from other sources.
conclusionsOur findings suggest that the meat pathway may be an important source of human infection with some clades of Salmonella Enteritidis ST11 in East Africa, but not of human infection by Salmonella Typhimurium ST313. Research is needed to systematically examine the contributions of other types of meat, animal products, produce, water, and the environment to nontyphoidal Salmonella disease in East Africa.
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