SynthesisSports health
Is Low-Intensity Isometric Handgrip Exercise an Efficient Alternative in Lifestyle Blood Pressure Management? A Systematic Review.
Synthesis in Sports health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07665034 (The Impact of Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension: A Study of Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The Optimal Dosage of Isometric Handgrip Exercise for Blood Pressure Reduction: Systematic Review and Meta-Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2026Pooled it
- Isometric handgrip training, but not a single session, reduces blood pressure in individuals with hypertension: a systematic review and meta-analysis.Journal of human hypertension · 2023Pooled it
- Effect of isometric handgrip exercise on cognitive function: Current evidence, methodology, and safety considerations.Frontiers in physiology · 2022Pooled it
- Low-to-Moderate-Intensity Resistance Exercise Is More Effective than High-Intensity at Improving Endothelial Function in Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- The Effects of Resistance Training on Blood Pressure in Preadolescents and Adolescents: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Impact of body mass index on blood pressure and cardiovascular adaptation to isometric exercise training.European journal of applied physiology · 2026Trial
- Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week.Journal of clinical hypertension (Greenwich, Conn.) · 2023Trial
- Aerobic exercise, but not isometric handgrip exercise, improves endothelial function and arterial stiffness in patients with myocardial infarction undergoing coronary intervention: a randomized pilot study.BMC cardiovascular disorders · 2021Trial
- Rethinking Isometric Handgrip Exercise Prescription: A Commentary on Duration, Fatigue, and Blood Pressure Management.Health science reports · 2026Article
- Metabolic Dysfunction-Associated Steatotic Liver Disease and Low Handgrip Strength Are Associated with a Higher Risk of Cardiovascular Disease.Journal of obesity & metabolic syndrome · 2026Article
- The acute and chronic effects of local aerobic exercise on cardiovascular physiology.Experimental physiology · 2026Review
- Article
- Effects of the Intensity, Duration, and Muscle Mass of Isometric Handgrip Exercise on Neuromuscular Fatigue and Post-Exercise Blood Pressure Responses: A Crossover Study.Health science reports · 2026Article
- Pilot Study Assessing the Hemodynamic Impact and Post-Exercise Hypotension Induced by High- Versus Low-Intensity Isometric Handgrip in Patients with Ischemic Heart Disease.Journal of cardiovascular development and disease · 2025Article
- Defining Optimal Nutrition Behaviors to Determine Benefit-Cost Ratio of Federal Nutrition Education Programs.Nutrients · 2025Article
- The Western and Chinese exercise training for blood pressure reduction among hypertensive patients: An overview of systematic reviews.Journal of clinical hypertension (Greenwich, Conn.) · 2024Review
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Effect of Lower- versus Higher-Intensity Isometric Handgrip Training in Adults with Hypertension: A Randomized Controlled Trial.Journal of cardiovascular development and disease · 2022Article
- Effect of isometric exercise on blood pressure in prehypertensive and hypertensive individuals: protocol for a systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2022Article
- Urban Environment and Health: A Cross-Sectional Study of the Influence of Environmental Quality and Physical Activity on Blood Pressure.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextHigh blood pressure is one of the leading preventable causes of cardiovascular death worldwide. In this regard, several studies have shown interest in the benefits of isometric exercise on blood pressure regulation.
objectiveTo assess whether low-intensity isometric handgrip exercise (LI-IHE) is an effective strategy to lower blood pressure levels in prehypertensive and hypertensive patients. DATA SOURCE: This study was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and registered with PROSPERO. Potentially eligible studies were identified after a systematic search conducted on 4 international databases: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), PEDro, and SPORTDiscus. STUDY SELECTION: We included randomized controlled trials that comprised patients who received LI-IHE. STUDY
designSystematic review with meta-analysis. LEVEL OF EVIDENCE: Level 3. DATA EXTRACTION: Data related to patient characteristics, exercise programs, risk-of-bias assessment, and outcomes of interest were systematically reviewed independently by 2 authors.
resultsThe following reductions (mean differences) were observed after LI-IHE: systolic blood pressure (SBP), (MD) = -5.43 mm Hg; (95% CI, -8.47 to -2.39;
conclusionLI-IHE seems to lower SBP, DBP, and MAP values in prehypertensive and hypertensive adults. It appears that LI-IHE reduces, in greater magnitude, blood pressure levels in hypertensive patients, specifically in patients aged <45 years, those who are overweight, and those on medications. Nevertheless, substantial heterogeneity in the main results and in the analyses by subgroups generated uncertainty about the real reduction magnitude that LI-IHE can produce on blood pressure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.