Evidence map›Paper›PMID 32776799›Full record

SynthesisThe Journal of international medical research2020

Dexmedetomidine versus magnesium sulfate as an adjuvant to local anesthetics in spinal anesthesia: a meta-analysis of randomized controlled trials.

Jinguo Wang, Zaitang Wang, Xuesong Song, Na Wang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Determination of Median Effective Concentration (ECDrug design, development and therapy · 2026
    Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jinguo WangDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin, China.
Zaitang WangDepartment of Taxation, School of Public Economics and Administration of Shanghai University of Finance and Economics, Changchun, Jilin, China.
Xuesong SongDepartment of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China.
Na WangDepartment of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China.ORCID https://orcid.org/0000-0002-8312-9787
Jilin University · CNJilin University of Finance and Economics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the efficacy of dexmedetomidine and magnesium sulfate as an adjuvant to local anesthetics in spinal anesthesia.

methodsA search of PubMed, Medline, Embase, the Cochrane Library, and Google Scholar was performed. Randomized controlled trials comparing the efficacy of dexmedetomidine and magnesium sulfate as a local anesthetic adjuvant in spinal anesthesia were identified. The primary outcome was sensory block duration. The mean difference (MD) or odds ratio along with the 95% confidence interval (CI) was used to analyze the outcomes.

resultsSix studies involving 360 patients were included. Intrathecal dexmedetomidine was associated with a significantly longer sensory block duration (MD = -73.62; 95% CI = -101.09 to -46.15), faster onsets of sensory blockade and motor blockade, and a longer motor block duration than intrathecal magnesium sulfate. There was no significant difference between the regarding the rates of hypotension, bradycardia, shivering, and postoperative nausea and vomiting between the groups.

conclusionsDexmedetomidine is superior to magnesium sulfate as an adjuvant to local anesthetics in spinal anesthesia because of its more rapid onset and longer duration of spinal block without significant adverse effects.

Indexed as

Anesthesia, SpinalDexmedetomidineAnesthetics, LocalHumansMagnesium SulfateRandomized Controlled Trials as TopicAnesthetics, LocalDexmedetomidineMagnesium SulfateadjuvantdexmedetomidinemagnesiumMeta-analysisrandomized controlled trialsensory blockspinal anesthesia

Identifiers

PMID32776799
PMCPMC7543129
OpenAlexW3047880917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.