Evidence map›Paper›PMID 32776794›Full record

SynthesisThe Journal of international medical research2020

Adductor canal block combined with local infiltration analgesia versus isolated adductor canal block in reducing pain and opioid consumption after total knee arthroplasty: a systematic review and meta-analysis.

Jianyong Lv, Cuiyuan Huang, Zuofeng Wang, Shan Ou

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06740214 (Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06740214 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2028Enrolled177ConditionsPain, Postoperative, Analgesic Effect, Total Knee Arthroplasty, Liposomal BupivacaineArms0.5% standard bupivacaine only, 1.33% liposomal bupivacaine with 0.5% standard bupivacaine, 1.33% liposomal bupivacaine only
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianyong LvDepartment of Anaesthesiology, Chengdu First People's Hospital, Chengdu, Sichuan Province, China.
Cuiyuan HuangDepartment of Anaesthesiology, Chengdu First People's Hospital, Chengdu, Sichuan Province, China.
Zuofeng WangDepartment of Anaesthesiology, Chengdu First People's Hospital, Chengdu, Sichuan Province, China.
Shan OuDepartment of Anaesthesiology, Chengdu First People's Hospital, Chengdu, Sichuan Province, China.ORCID https://orcid.org/0000-0001-9690-364X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the efficacy and safety of the addition of local infiltration analgesia (LIA) to adductor canal block (ACB) for pain control after primary total knee arthroplasty (TKA).

methodsTwo reviewers independently searched for potentially relevant published studies using electronic databases, including PubMed® (1966 to June 2019), Embase® (1974 to June 2019) and Web of Science (1990 to June 2019). The results were pooled using the random-effects model to produce standard mean differences for continuous outcome data and odds ratio for categorical outcome data.

resultsA total of three randomized controlled trials (RCTs) and three non-RCTs were included for data extraction and meta-analysis. There were significant differences between the two groups regarding the postoperative pain score on postoperative day (POD) 0 and POD 1. The cumulative opioid consumption in the ACB plus LIA groups was significantly lower than that in the ACB groups on POD 0 and POD 1. No significant differences were found in terms of postoperative range of motion or length of hospitalization.

conclusionACB plus LIA significantly reduced the postoperative pain score on POD 0 and POD 1 compared with isolated ACB. In addition, ACB plus LIA was associated with a significant reduction in opioid consumption during the early postoperative period.

Indexed as

AnalgesiaArthroplasty, Replacement, KneeNerve BlockAnalgesics, OpioidHumansPostoperative PainAnalgesics, Opioidadductor canal blocklocal infiltration analgesiameta-analysisopioidTotal knee arthroplasty

Identifiers

PMID32776794
PMCPMC7557703

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.