Evidence map›Paper›PMID 32776782›Full record

ArticleThe American surgeon2020

Intraoperative Radiation Therapy Versus Whole Breast Radiation for Early-Stage Breast Cancer Treatment in Rural Appalachia.

Jad M Abdelsattar, Katherine McClain, Faryal G Afridi, Sijin Wen, Yilin Cai, Kelsey A Musgrove, Kimberly Bailey, Parvez M Shaikh, Geraldine M Jacobson, Wallis Marsh and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American surgeon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jad M Abdelsattar24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Katherine McClainSchool of Medicine, West Virginia University, Morgantown, WV, USA.
Faryal G Afridi24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Sijin WenDepartment of Biostatistics, West Virginia University, Morgantown, WV, USA.
Yilin CaiDepartment of Biostatistics, West Virginia University, Morgantown, WV, USA.
Kelsey A Musgrove24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Kimberly Bailey24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Parvez M ShaikhDepartment of Radiation Oncology, West Virginia University, Morgantown, WV, USA.
Geraldine M JacobsonDepartment of Radiation Oncology, West Virginia University, Morgantown, WV, USA.
Wallis Marsh24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Kristin Lupinacci24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Michael S Cowher24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
Hannah Hazard Jenkins24041 Department of Surgery, West Virginia University, Morgantown, WV, USA.
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

backgroundIntraoperative radiation therapy (IORT) is an alternate accelerated form of radiation following breast-conserving surgery (BCS). Lack of data regarding long-term outcomes has limited adoption. We report our experience with IORT in patients undergoing BCS versus whole breast radiation therapy (WBRT).

methodsRetrospective review of patients undergoing BCS with IORT versus WBRT (2012-2017). Inclusion: low grade, T1-2N0M0, estrogen receptor/progesterone receptor positive, and Her2-negative infiltrating ductal carcinomas. IORT was delivered as a single fraction of radiation (20 Gy) intraoperatively. Outcomes were compared using Fisher's test for discrete variables or Wilcoxon signed-rank test for continuous variables. Kaplan-Meier method was used to estimate disease-free survival (DFS).

resultsFifty-one patients (44%) received IORT, and 66 (56%) received WBRT. There was no difference in age, tumor size, receptor status, or in-breast recurrence (1.9% vs 0%, all DISCUSSION: IORT produces noninferior oncologic outcomes and decreased skin toxicity compared with WBRT. It can be convenient for patients in rural regions with limited health care access.

Indexed as

AdultAppalachian RegionBreast NeoplasmsDose Fractionation, RadiationFemaleHumansIntraoperative CareMastectomy, SegmentalRadiotherapy, AdjuvantRetrospective StudiesRural Population

Identifiers

PMID32776782
PMCPMC8366587
OpenAlexW3048684189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.