ArticleJournal of biomedical materials research. Part A2021
Three-dimensionally printed polycaprolactone/beta-tricalcium phosphate scaffold was more effective as an rhBMP-2 carrier for new bone formation than polycaprolactone alone.
Article in Journal of biomedical materials research. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3D printed scaffolds loaded with BMP-2 for bone defect regeneration: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Effects of polycaprolactone/hydroxyapatite nanocomposite scaffolds combined with platelet-rich fibrin for repair of rabbit calvarial bone defects.Veterinary research forum : an international quarterly journal · 2026Article
- The Novel Osteopore® Wedge in Medial Opening Wedge High Tibial Osteotomy: A Technical Note.Cureus · 2025Article
- Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation.Materials today. Bio · 2025Review
- Mechanical and biological properties of 3D printed bone tissue engineering scaffolds.Frontiers in bioengineering and biotechnology · 2025Review
- 3D-Printed Demineralized Bone Matrix-Based Conductive Scaffolds Combined with Electrical Stimulation for Bone Tissue Engineering Applications.ACS applied bio materials · 2024Article
- Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances.Bioactive materials · 2024Review
- 3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects.Journal of biological engineering · 2024Article
- Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review.Journal of functional biomaterials · 2023Article
- Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones.Biomedicines · 2023Review
- Recent advances on 3D-printed PCL-based composite scaffolds for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration.The Japanese dental science review · 2022Review
- Clinically relevant preclinical animal models for testing novel cranio-maxillofacial bone 3D-printed biomaterials.Clinical and translational medicine · 2022Review
- The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering.Polymers · 2021Review
- 3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects.Materials (Basel, Switzerland) · 2021Article
- Three-dimensionally printed polycaprolactone/beta-tricalcium phosphate scaffold was more effective as an rhBMP-2 carrier for new bone formation than polycaprolactone alone.Journal of biomedical materials research. Part A · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombinant human bone morphogenetic protein 2 (rhBMP-2) has been widely used in bone tissue engineering to enhance bone regeneration because of its osteogenic inductivity. However, clinical outcomes can vary depending on the scaffold materials used to deliver rhBMP-2. In this study, 3D-printed scaffolds with a ratio of 1:1 polycaprolactone and beta-tricalcium phosphate (PCL/T50) were applied as carriers for rhBMP-2 in mandibular bone defect models in dog models. Before in vivo application, in vitro experiments were conducted. Preosteoblast proliferation was not significantly different between scaffolds made of PCL/T50 and polycaprolactone alone (PCL/T0) regardless of rhBMP-2 delivery. However, PCL/T50 showed an increased level of the alkaline phosphatase activity and mineralization assay when rhBMP-2 was delivered. In in vivo, the newly formed bone volume of the PCL/T50 group was significantly increased compared with that of the PCL/T0 scaffolds regardless of rhBMP-2 delivery. Histological examination showed that PCL/T50 with rhBMP-2 produced significantly greater amounts of newly bone formation than PCL/T0 with rhBMP-2. The quantities of scaffold remaining were lower in the PCL/T50 group than in the PCL/T0 group, although it was not significantly different. In conclusion, PCL/T50 scaffolds were advantageous for rhBMP-2 delivery as well as for maintaining space for bone formation in mandibular bone defects.
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