Evidence map›Paper›PMID 32776491›Full record

ArticlePharmacology research & perspectives2020

In vitro metabolic profile and drug-drug interaction assessment of secnidazole, a high-dose 5-nitroimidazole antibiotic for the treatment of bacterial vaginosis.

Helen S Pentikis, Nikki Adetoro, Gregory Kaufman

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Helen S PentikisSAJE Consulting, Baltimore, MD, USA.
Nikki AdetoroLupin Pharmaceuticals, Baltimore, MD, USA.
Gregory KaufmanLupin Pharmaceuticals, Baltimore, MD, USA.
Lupin Pharmaceuticals (United States) · USRED Consulting (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A single-dose oral granule formulation of secnidazole 2 g (SOLOSEC

Indexed as

Aldehyde DehydrogenaseAnti-Bacterial AgentsCells, CulturedCytochrome P-450 Enzyme SystemDose-Response Relationship, DrugDrug InteractionsHepatocytesHumansInhibitory Concentration 50MetronidazoleMicrosomes, LiverTime FactorsAldehyde DehydrogenaseAnti-Bacterial AgentsCytochrome P-450 Enzyme SystemMetronidazolesecnidazoleantibioticbacterial vaginosissecnidazole

Identifiers

PMID32776491
PMCPMC7416039
OpenAlexW3047862026

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.