Evidence map›Paper›PMID 32775979›Full record

ArticleKidney medicine

Association Between Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study.

Jennifer S Yokoyama, Mina Matsuda-Abedini, Michelle R Denburg, Juhi Kumar, Bradley A Warady, Susan L Furth, Stephen R Hooper, Anthony A Portale, Farzana Perwad

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00327860 recruitingnot on this map

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2003 to 2028Enrolled1,300ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. How FGF23 shapes multiple organs in chronic kidney disease.Molecular and cellular pediatrics · 2021
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer S YokoyamaDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA.
Mina Matsuda-AbediniDivision of Nephrology, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Michelle R DenburgChildren's Hospital of Philadelphia, Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Juhi KumarDivision of Nephrology, Weill Cornell Medical College, New York, NY.
Bradley A WaradyDivision of Nephrology, Children's Mercy Kansas City, Kansas City, MO.
Susan L FurthChildren's Hospital of Philadelphia, Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Stephen R HooperDepartment of Allied Health Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Anthony A PortaleDivision of Nephrology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Farzana PerwadDivision of Nephrology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA.

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U24DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Derek K Ng · 2018 to 2026
$12.6M
NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U24 DK066116
6 · The paper itself

Abstract

RATIONALE &

objectiveChronic kidney disease (CKD) in children is associated with cognitive dysfunction that affects school performance and quality of life. The relationship between CKD-mineral and bone disorder and cognitive function in children is unknown. STUDY

designObservational study.

participants702 children enrolled in the Chronic Kidney Disease in Children (CKiD) Study. PREDICTORS: Plasma fibroblast growth factor 23 (FGF-23), parathyroid hormone (PTH), calcium, phosphorus, 25 hydroxyvitamin D (25[OH]D), and 1,25 dihydroxyvitamin D (1,25[OH] OUTCOMES: Neurocognitive tests of intelligence, academic achievement, and executive functions. ANALYTICAL APPROACH: Linear regression models to analyze the cross-sectional associations between log

resultsAt baseline, median age was 12 (95% CI, 8.3, 15.2) years and estimated glomerular filtration rate was 54 (40.5, 67.8) mL/min/1.73 m LIMITATIONS: The study does not assess the cumulative effects of FGF-23 excess on cognitive function over time. Within-population stratified analyses were not performed due to limited sample size.

conclusionsIn children with CKD, higher plasma FGF-23 level is associated with lower performance in targeted tests of executive function, specifically attention regulation, independent of glomerular filtration rate.

Indexed as

chronic kidney diseasecognitionFGF-23pediatric

Identifiers

PMID32775979
PMCPMC7406846

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.