ArticleKidney international reports2020
Serum Uric Acid and Mortality Risk Among Hemodialysis Patients.
Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on serum uric acid levels in patients with chronic kidney disease: a systematic review and network meta-analysis.BMJ open diabetes research & care · 2024Pooled it
- Serum uric acid-to-albumin ratio as a novel predictor of all-cause mortality and cardiovascular events in hemodialysis patients: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Higher serum Metrnl levels are associated with increased vascular calcification in hemodialysis patients.Renal failure · 2025Article
- Correlation Analysis of Serum Uric Acid and Uric Acid Creatinine Ratio With Sarcopenia in the Elderly.Aging medicine (Milton (N.S.W)) · 2025Article
- Association between the serum uric acid-to-creatinine ratio and cardiovascular mortality in maintenance hemodialysis patients.Renal failure · 2025Article
- Serum Uric Acid Level as an Estimated Parameter That Predicts All-Cause Mortality in Patients with Hemodialysis.Journal of personalized medicine · 2025Article
- Lower time-averaged serum uric acid was associated with increased mortality in peritoneal dialysis patients.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025Article
- J-shaped association of serum uric acid with all-cause and cardiovascular mortality in patients with diabetic kidney disease.Acta diabetologica · 2025Article
- Hyperuricemia prevalence and its risk factors in uremic patients undergoing maintenance hemodialysis.BMC nephrology · 2025Article
- Impact of Uric Acid Levels on Mortality and Cardiovascular Outcomes in Relation to Kidney Function.Journal of clinical medicine · 2024Article
- Review
- Long-Term Survival of Patient with End-Stage Renal Disease Using Bayesian Mixture Cure Rate Frailty Models.Iranian journal of public health · 2024Article
- Association between serum uric acid and all-cause and cardiovascular-related mortality in hemodialysis patients.Frontiers in nutrition · 2024Article
- Association of serum uric acid with all-cause and cardiovascular mortality in obstructive sleep apnea.Scientific reports · 2023Article
- Longitudinal uric acid has nonlinear association with kidney failure and mortality in chronic kidney disease.Scientific reports · 2023Article
- Urate-lowering therapy for patients with gout on hemodialysis.International journal of rheumatic diseases · 2022Article
- The association between the serum uric acid to creatinine ratio and all-cause mortality in elderly hemodialysis patients.BMC nephrology · 2022Article
- Uric Acid, Ferritin, Albumin, Parathyroid Hormone and Gamma-Glutamyl Transferase Concentrations are Associated with Uremic Cardiomyopathy Characteristics in Non-Dialysis and Dialysis Chronic Kidney Disease Patients.International journal of nephrology and renovascular disease · 2022Article
- Cognitive Domain Impairment and All-Cause Mortality in Older Patients Undergoing Hemodialysis.Frontiers in endocrinology · 2022Article
- Comparison of Inflammatory Markers in the Diagnosis of Metabolic Syndrome in Hemodialysis Patients: A Multicenter Observational Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough high serum uric acid (SUA) has been consistently associated with an increased risk of death in the general population and in persons with nondialysis chronic kidney disease (CKD), studies in patients undergoing dialysis are conflicting. It has been postulated that low SUA simply reflects poor nutritional status in dialysis patients. We here characterize the association between SUA and the risk of death in a large dialysis cohort and explore effect modification by underlying nutritional status as reflected by body composition.
methodsIn this retrospective cohort study, we included 16,057 hemodialysis (HD) patients treated during 2007 to 2016 in NephroCare centers as recorded in the European Clinical Database (EuCliD). The association between SUA, all-cause, and cardiovascular (CV)-related mortality was evaluated with competing risk models and characterized with splines. Effect modification was explored by lean tissue index (LTI) and fat tissue index (FTI).
resultsDuring a mean of 1.8 years of follow-up, 2791 patients (17.4%) died. We found a multivariable-adjusted U-shaped pattern between SUA and all-cause mortality. Patients with SUA levels of 6.5 mg/dl (387 μmol/l) were at the lowest risk of death (subdistribution hazard ratio = 0.94 [confidence interval {CI} 0.91; 0.96]). The form of association was not meaningfully affected by underlying LTI and FTI.
conclusionWe found a U-shaped pattern between SUA levels and all-cause mortality among HD patients, which was independent of the patients' body composition.
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