Evidence map›Paper›PMID 32775817›Full record

ArticleKidney international reports2020

Use of Desmopressin Prior to Kidney Biopsy in Patients With High Bleeding Risk.

Simon Leclerc, Annie-Claire Nadeau-Fredette, Naoual Elftouh, Jean-Philippe Lafrance, Vincent Pichette, Louis-Philippe Laurin

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06622187 (Bleeding Prevention With Desmopressin for Allograft Kidney Biopsies), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06622187 phase4enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Bleeding Prevention With Desmopressin for Allograft Kidney Biopsies: a Double-blind Randomized Study

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2024 to 2026Enrolled96ConditionsBleeding, Transplant, Kidney, Desmopressin, Kidney BiopsyArmsDesmopressin (DDAVP), Sodium Chloride
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  11. When our intuition lets us down-something believed to be beneficial may actually be harmful.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
  12. Article
  13. The Role of Desmopressin in Kidney Biopsies: A Narrative Review.Canadian journal of kidney health and disease · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Simon LeclercDivision of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Annie-Claire Nadeau-FredetteDivision of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Naoual ElftouhResearch Center, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Jean-Philippe LafranceDivision of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Vincent PichetteDivision of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Louis-Philippe LaurinDivision of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Hôpital Maisonneuve-Rosemont · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo prevent bleeding after native kidney biopsy (NKB), nephrologists often prescribe desmopressin, especially for patients with reduced estimated glomerular filtration rate (eGFR) at risk of uremia-related platelet dysfunction. However, only 1 randomized study has suggested a beneficial effect for desmopressin in patients with eGFR ≥60 ml/min per 1.73 m

methodsIn this retrospective cohort study, all adult patients who underwent an NKB from April 1, 2013, to April 30, 2018, in a tertiary hospital were identified. The association between desmopressin use and bleeding complications, including hemoglobin fall, transfusion, hematoma, symptomatic hematoma, urgent radiologic study, and hypotension, was analyzed using multivariable logistic regression models.

resultsA total of 413 native kidney biopsies were studied, 79% of which were performed after receiving desmopressin. Patients receiving desmopressin had worse chronic kidney disease (eGFR 28 vs. 45 ml/min per 1.73 m

conclusionPatients at higher risk of bleeding using desmopressin before kidney biopsy had bleeding complications similar to those not using desmopressin. These results highlight potential important clinical and financial benefits of desmopressin use before kidney biopsy.

Indexed as

bleedingcomplicationdesmopressinkidney biopsyradiologic studies

Identifiers

PMID32775817
PMCPMC7403497
OpenAlexW3026763667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.