ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.
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Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Cross-ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025Review
- Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts.medRxiv : the preprint server for health sciences · 2025Article
- The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A survey on deep learning for polygenic risk scores.Briefings in bioinformatics · 2025Review
- Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement.Genome medicine · 2024Article
- Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Machine learning approaches to identify systemic lupus erythematosus in anti-nuclear antibody-positive patients using genomic data and electronic health records.BioData mining · 2024Article
- The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing.PloS one · 2024Article
- Charting the Next Road Map for CSF Biomarkers in Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Deep learning-based polygenic risk analysis for Alzheimer's disease prediction.Communications medicine · 2023Article
- Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case-control study in mainland China.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records.Frontiers in aging neuroscience · 2022Article
- Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk.Journal of Alzheimer's disease : JAD · 2022Article
- Demographics and Medication Use of Patients with Late-Onset Alzheimer's Disease in Hong Kong.Journal of Alzheimer's disease : JAD · 2022Article
- Current and Future Trends in Biomarkers for the Early Detection of Alzheimer's Disease in Asia: Expert Opinion.Journal of Alzheimer's disease reports · 2022Review
- Article
- Associations of Polygenic Risk Score for Late-Onset Alzheimer's Disease With Biomarkers.Frontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 3 countries.
Xiaopu ZhouDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Yu ChenDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Fanny C F IpDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Nicole C H LaiDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Yolanda Y T LiDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Yuanbing JiangDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Huan ZhongDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Yuewen ChenDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Yulin ZhangGuangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
Shuangshuang MaGuangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
Ronnie M N LoDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Kit CheungDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Estella P S TongDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Ho KoDivision of Neurology Department of Medicine and Therapeutics Li Ka Shing Institute of Health Sciences School of Biomedical Sciences Gerald Choa Neuroscience Center Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong China.
Maryam ShoaiDepartment of Neurodegenerative Disease UCL Institute of Neurology London UK.
Kin Y MokDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
John HardyHong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.
Vincent C T MokGerald Choa Neuroscience Centre Lui Che Woo Institute of Innovative Medicine Therese Pei Fong Chow Research Centre for Prevention of Dementia Division of Neurology Department of Medicine and Therapeutics The Chinese University of Hong Kong Shatin Hong Kong China.
Timothy C Y KwokTherese Pei Fong Chow Research Centre for Prevention of Dementia Division of Geriatrics Department of Medicine and Therapeutics The Chinese University of Hong Kong Shatin Hong Kong China.
Amy K Y FuDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Nancy Y IpDivision of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Hong Kong University of Science and Technology · HKChinese University of Hong Kong · HKHKUST Shenzhen Research Institute · CNChinese Academy of Sciences · CNUniversity College London · GB
Funding
Medical Research Council G0701075Medical Research Council G0901254Medical Research Council MR/L501542/1Medical Research Council MR/N026004/1Parkinson's UK G-0907
Abstract
introductionDozens of Alzheimer's disease (AD)-associated loci have been identified in European-descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population.
methodsTaqMan array genotyping was performed for known AD-associated variants in a Hong Kong Chinese cohort. Regression analysis was conducted to study the associations of variants with AD-associated traits and biomarkers. Lasso regression was applied to establish a polygenic risk score (PRS) model for AD risk prediction.
resultsDISCUSSION:
Indexed as
Alzheimer's diseasedisease riskpolygenic risk scorepopulation geneticsSORL1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.