ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Semantic loss marks early Alzheimer's disease-related neurodegeneration in older adults without dementia.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Digital speech-based markers to advance prognosis in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multimodal neuroimaging and electrophysiological signatures in amnestic mild cognitive impairment with different amyloid-β deposition status: correlations with cognitive function and diagnostic value.Frontiers in aging neuroscience · 2026Article
- Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Utility of a Short-Form Phonemic Fluency Task.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Contribution of Global Amyloid-PET Imaging for Predicting Future Cognition in the MEMENTO Cohort.Neurology · 2024Article
- Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Quantitative estimate of cognitive resilience and its medical and genetic associations.Alzheimer's research & therapy · 2023Article
- Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA.Scientific reports · 2023Article
- Longitudinal decline in semanticJournal of the International Neuropsychological Society : JINS · 2023Article
- Neuropsychological predictors of conversion from mild cognitive impairment to dementia at different timepoints.Brain and behavior · 2023Article
- Semantic item-level metrics relate to future memory decline beyond existing cognitive tests in older adults without dementia.Psychology and aging · 2023Article
- Application of the Semantic Fluency Test in the Screening of Mandarin-Chinese-Speaking Older Adults with Mild Dementia of the Alzheimer Type.Behavioral sciences (Basel, Switzerland) · 2023Article
- N-acetyl-aspartate and Myo-inositol as Markers of White Matter Microstructural Organization in Mild Cognitive Impairment: Evidence from a DTI-Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Editorial: The mechanistic and clinical principles of item-level scoring methods applied to the category fluency test and other tests of semantic memory.Frontiers in psychology · 2023Article
- The relation of ApoE and COMT gene-gene interactions to cognitive and motor function in community-dwelling older adults: a pilot study.Frontiers in aging neuroscience · 2023Article
- Bear in mind: the role of personal background in semantic animal fluency - The SMART-MR study.Frontiers in psychology · 2023Article
- The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Research on Voxel-Based Features Detection and Analysis of Alzheimer's Disease Using Random Survey Support Vector Machine.Frontiers in neuroinformatics · 2022Article
- Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
19 authors at 12 institutions in 5 countries.
Funding
Abstract
objectiveTo assess progression of semantic loss in early stages of cognitive decline using semantic and letter fluency performance, and its relation with Alzheimer's disease (AD)-specific neurodegeneration using longitudinal multimodal neuroimaging measures.
methodsChange in verbal fluency was analyzed among 2261 non-demented individuals with a follow-up diagnosis of no mild cognitive impairment (MCI), amnestic MCI (aMCI), non-amnestic MCI (naMCI), or incident dementia, using linear mixed models across 4 years of follow-up, and relations with magnetic resonance imaging (MRI; n = 1536) and
resultsSemantic fluency declined-fastest in those at higher risk for AD (apolipoprotein E [APOE] e4 carriers, Clinical Dementia Rating score of .5, aMCI, or incident dementia)-while letter fluency did not except for those with incident dementia. Lower baseline semantic fluency was associated with an increase in white matter hyperintensities and total mean cortical thinning over time, and regionally with less hippocampal volume as well as more cortical thinning and reduced
interpretationThis study provides strong evidence of distinctive degeneration of semantic abilities early on in relation to both cognitive decline and AD-specific neurodegeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.