Evidence map›Paper›PMID 32775471›Full record

ArticleJournal of immunology research2020

Altered Regulatory B Cell Subsets in Children with Type 1 Diabetes Mellitus.

Mohamed A El-Mokhtar, Nahla M Elsherbiny, Douaa Sayed, Duaa M Raafat, Eman Askar, Almontaser Hussein, Mohamed A Y Abdel-Malek, Amira M Shalaby

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Altered B cell metabolic pathways characterize type 1 diabetes progression.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Differences of Circulating CD25Journal of immunology research · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Observational
  16. Regulatory B Cells: Role in Type 1 Diabetes.Frontiers in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mohamed A El-MokhtarDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt.ORCID https://orcid.org/0000-0003-1943-8419
Nahla M ElsherbinyDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt.
Douaa SayedDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt.ORCID https://orcid.org/0000-0002-4083-3942
Duaa M RaafatDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.
Eman AskarDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.
Almontaser HusseinDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.
Mohamed A Y Abdel-MalekAssiut University Children's Hospital, Faculty of Medicine, Assiut University, Egypt.ORCID https://orcid.org/0000-0002-2311-1104
Amira M ShalabyDepartment of Pediatrics, Faculty of Medicine, Assiut University, Egypt.
Assiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B regulatory cells (Breg) refer to characteristic subsets of B cells that generally exert anti-inflammatory functions and maintain peripheral tolerance mainly through their ability to secrete interleukin-10 (IL10). Dysregulation in the function of Breg cells was reported in several autoimmune diseases. However, the relation between Breg and children with type 1 diabetes (T1D) is poorly understood. Thus, this study is aimed at determining whether Breg cells play a role in T1D in children or not, so we hypothesized that an altered phenotype of B cell subsets is associated with T1D in children. Children with T1D (

Indexed as

ADP-ribosyl Cyclase 1AutoantibodiesAutoimmune DiseasesBlood GlucoseB-Lymphocytes, RegulatoryCD24 AntigenChildChild, PreschoolDiabetes Mellitus, Type 1FemaleHumansImmune ToleranceInflammationInterleukin-10Islets of LangerhansMaleADP-ribosyl Cyclase 1AutoantibodiesBlood GlucoseCD24 AntigenInterleukin-10Tumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID32775471
PMCPMC7391103
OpenAlexW3045310368

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.