Evidence map›Paper›PMID 32775198›Full record

ArticlePhotoacoustics2020

Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment.

Eno Hysi, Muhannad N Fadhel, Yanjie Wang, Joseph A Sebastian, Anoja Giles, Gregory J Czarnota, Agata A Exner, Michael C Kolios

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Early Radiation Therapy Response Assessment Using Multi-Scale Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Eno HysiDepartment of Physics, Ryerson University, Toronto, Canada.
Muhannad N FadhelDepartment of Physics, Ryerson University, Toronto, Canada.
Yanjie WangDepartment of Physics, Ryerson University, Toronto, Canada.
Joseph A SebastianDepartment of Physics, Ryerson University, Toronto, Canada.
Anoja GilesDeparment of Radiation Oncology, Sunnybrook Health Sciences Center, Toronto, Canada.
Gregory J CzarnotaDeparment of Radiation Oncology, Sunnybrook Health Sciences Center, Toronto, Canada.
Agata A ExnerDepartment of Radiology, Case Western Reserve University, Cleveland, United States.
Michael C KoliosDepartment of Physics, Ryerson University, Toronto, Canada.
St. Michael's Hospital · CASunnybrook Health Science Centre · CACase Western Reserve University · US

Funding

Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMAR01EB025741 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI James Peter Basilion, Agata A Exner · 2018 to 2026
$4.1M
NIBIB NIH HHS R01 EB025741
6 · The paper itself

Abstract

The development of novel anticancer therapies warrants the parallel development of biomarkers that can quantify their effectiveness. Photoacoustic imaging has the potential to measure changes in tumor vasculature during treatment. Establishing the accuracy of imaging biomarkers requires direct comparisons with gold histological standards. In this work, we explore whether a new class of submicron, vascular disrupting, ultrasonically stimulated nanobubbles enhance radiation therapy.

Indexed as

MicrobubblesNanobubblesPhotoacoustic imagingRadiation therapyVascular disruption

Identifiers

PMID32775198
PMCPMC7393572
OpenAlexW3044851174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.