ArticleJournal of oral biology and craniofacial research
Topical 5-fluorouracil application in management of odontogenic keratocysts.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Exploring the use and efficacy of 5-fluorouracil in the management of odontogenic keratocysts: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- 5-fluorouacil in the treatment of odontogenic keratocysts-incidence of recurrence and inferior alveolar nerve paresthesia: a systematic review.Oral and maxillofacial surgery · 2023Pooled it
- Management of a Mandibular Odontogenic Keratocyst with Enucleation, Piezotome-Assisted Peripheral Ostectomy, and Platelet-Rich Fibrin-A Case Report.Dentistry journal · 2025Article
- Article
- The Role of 5-Fluorouracil in Preventing Recurrence After Enucleation of Odontogenic Keratocyst: A Case Report.Cureus · 2023Article
- Antimetabolite in the Management of Odontogenic Keratocyst-A Case Report.Journal of maxillofacial and oral surgery · 2023Article
- Combined conservative treatment of a recurrent mandibular keratocyst by enucleation, diode laser, 5-Fluorouracil and dental implants: a case report with 18 years-follow up.Medicine and pharmacy reports · 2023Article
- Comparison of the effectiveness of 5-Fluorouracil and modified Carnoy's solution in reducing the recurrence of odontogenic keratocyst.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIM &
objectivesThe aim of this study was to evaluate the efficacy of topical application of 5-fluorouracil (5-FU) after peripheral ostectomy, and compare it with other treatment modalities in the management of odontogenic keratocyst (OKC). MATERIALS &
methodsThis prospective study was conducted in the OMFS department for last seven years, wherein twenty seven patients of OKC were included and randomly allocated to the three treatment groups. Nine were treated by enucleation followed by application of modified carnoy solution (CS), eleven by peripheral ostectomy followed by application of 5-FU and eleven by segmental resection (SR). Follow-up ranged from 2 to 4 years to assess bone healing and record any recurrence of lesion.
resultsAmongst twenty seven patients, eighteen were males and nine females, age range 20-66 years. The most common location of OKC was posterior mandible. Complications included nerve injury, swelling, infection, and recurrence (66.6% after modified CS). Functional and aesthetic compromise was seen in resection patients whereas application of 5-FU had minimal nerve injuries, infection, swelling, no recurrence with no compromise in aesthetics and function.
conclusionManagement of OKC by 5-FU is a novel surgical method having less morbidity, minimal recurrence, low cost, no functional or cosmetic deformity.
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